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Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

Overview of attention for article published in Journal of Translational Medicine, July 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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3 X users
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4 patents

Citations

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54 Dimensions

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80 Mendeley
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Title
Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer
Published in
Journal of Translational Medicine, July 2016
DOI 10.1186/s12967-016-0948-z
Pubmed ID
Authors

Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhin G. Concannon, Elaine W. Kay, Deborah A. McNamara, Jochen H. M. Prehn

Abstract

Colorectal cancer (CRC) is a leading cause of cancer mortality in the Western world and commonly treated with genotoxic chemotherapy. Stress in the endoplasmic reticulum (ER) was implicated to contribute to chemotherapeutic resistance. Hence, ER stress related protein may be of prognostic or therapeutic significance. The expression levels of ER stress proteins calnexin, calreticulin, GRP78 and GRP94 were determined in n = 23 Stage II and III colon cancer fresh frozen tumour and matched normal tissue samples. Data were validated in a cohort of n = 11 rectal cancer patients treated with radiochemotherapy in the neoadjuvant setting. The calnexin gene was silenced using siRNA in HCT116 cells. There were no increased levels of ER stress proteins in tumour compared to matched normal tissue samples in Stage II or III CRC. However, increased calnexin protein levels were predictive of poor clinical outcome in the patient cohort. Data were validated in the rectal cancer cohort treated in the neoadjuvant setting. Calnexin gene-silencing significantly reduced cell survival and increased cancer cell susceptibility to 5FU chemotherapy. Increased tumour protein levels of calnexin may be of prognostic significance in CRC, and calnexin may represent a potential target for future therapies.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 79 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 33%
Student > Bachelor 9 11%
Student > Master 9 11%
Researcher 8 10%
Student > Postgraduate 7 9%
Other 9 11%
Unknown 12 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 33%
Medicine and Dentistry 18 23%
Agricultural and Biological Sciences 9 11%
Chemistry 4 5%
Psychology 2 3%
Other 8 10%
Unknown 13 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2024.
All research outputs
#4,289,686
of 23,507,888 outputs
Outputs from Journal of Translational Medicine
#699
of 4,167 outputs
Outputs of similar age
#73,824
of 353,969 outputs
Outputs of similar age from Journal of Translational Medicine
#11
of 103 outputs
Altmetric has tracked 23,507,888 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,167 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,969 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.