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Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

Overview of attention for article published in Journal of Translational Medicine, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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3 tweeters

Citations

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10 Dimensions

Readers on

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36 Mendeley
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Title
Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer
Published in
Journal of Translational Medicine, July 2016
DOI 10.1186/s12967-016-0948-z
Pubmed ID
Authors

Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhin G. Concannon, Elaine W. Kay, Deborah A. McNamara, Jochen H. M. Prehn

Abstract

Colorectal cancer (CRC) is a leading cause of cancer mortality in the Western world and commonly treated with genotoxic chemotherapy. Stress in the endoplasmic reticulum (ER) was implicated to contribute to chemotherapeutic resistance. Hence, ER stress related protein may be of prognostic or therapeutic significance. The expression levels of ER stress proteins calnexin, calreticulin, GRP78 and GRP94 were determined in n = 23 Stage II and III colon cancer fresh frozen tumour and matched normal tissue samples. Data were validated in a cohort of n = 11 rectal cancer patients treated with radiochemotherapy in the neoadjuvant setting. The calnexin gene was silenced using siRNA in HCT116 cells. There were no increased levels of ER stress proteins in tumour compared to matched normal tissue samples in Stage II or III CRC. However, increased calnexin protein levels were predictive of poor clinical outcome in the patient cohort. Data were validated in the rectal cancer cohort treated in the neoadjuvant setting. Calnexin gene-silencing significantly reduced cell survival and increased cancer cell susceptibility to 5FU chemotherapy. Increased tumour protein levels of calnexin may be of prognostic significance in CRC, and calnexin may represent a potential target for future therapies.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 42%
Student > Postgraduate 5 14%
Researcher 5 14%
Student > Bachelor 3 8%
Student > Master 3 8%
Other 3 8%
Unknown 2 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 39%
Agricultural and Biological Sciences 7 19%
Medicine and Dentistry 4 11%
Immunology and Microbiology 2 6%
Psychology 2 6%
Other 4 11%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2016.
All research outputs
#3,394,550
of 7,974,292 outputs
Outputs from Journal of Translational Medicine
#555
of 1,800 outputs
Outputs of similar age
#103,873
of 260,687 outputs
Outputs of similar age from Journal of Translational Medicine
#31
of 99 outputs
Altmetric has tracked 7,974,292 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,800 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,687 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.