↓ Skip to main content

Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

Overview of attention for article published in Virology Journal, July 2016
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
80 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins
Published in
Virology Journal, July 2016
DOI 10.1186/s12985-016-0573-8
Pubmed ID
Authors

Hoai J. Ly, Tetsuro Ikegami

Abstract

Rift Valley fever is a mosquito-borne zoonotic disease that affects both ruminants and humans. The nonstructural (NS) protein, which is a major virulence factor for Rift Valley fever virus (RVFV), is encoded on the S-segment. Through the cullin 1-Skp1-Fbox E3 ligase complex, the NSs protein promotes the degradation of at least two host proteins, the TFIIH p62 and the PKR proteins. NSs protein bridges the Fbox protein with subsequent substrates, and facilitates the transfer of ubiquitin. The SAP30-YY1 complex also bridges the NSs protein with chromatin DNA, affecting cohesion and segregation of chromatin DNA as well as the activation of interferon-β promoter. The presence of NSs filaments in the nucleus induces DNA damage responses and causes cell-cycle arrest, p53 activation, and apoptosis. Despite the fact that NSs proteins have poor amino acid similarity among bunyaviruses, the strategy utilized to hijack host cells are similar. This review will provide and summarize an update of recent findings pertaining to the biological functions of the NSs protein of RVFV as well as the differences from those of other bunyaviruses.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 79 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 23%
Student > Master 13 16%
Researcher 11 14%
Student > Bachelor 10 13%
Professor > Associate Professor 5 6%
Other 16 20%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 34%
Biochemistry, Genetics and Molecular Biology 21 26%
Immunology and Microbiology 10 13%
Veterinary Science and Veterinary Medicine 5 6%
Chemistry 2 3%
Other 8 10%
Unknown 7 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#3,169,874
of 7,992,937 outputs
Outputs from Virology Journal
#505
of 1,626 outputs
Outputs of similar age
#92,203
of 260,505 outputs
Outputs of similar age from Virology Journal
#16
of 57 outputs
Altmetric has tracked 7,992,937 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 1,626 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.