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Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States

Overview of attention for article published in Parasites & Vectors, July 2012
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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1 tweeter
facebook
2 Facebook pages

Citations

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33 Dimensions

Readers on

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37 Mendeley
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Title
Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States
Published in
Parasites & Vectors, July 2012
DOI 10.1186/1756-3305-5-138
Pubmed ID
Authors

Dwight D Bowman

Abstract

In order to provide a background to current concerns relative to the possible resistance of heartworms to macrocyclic lactones, this review summarizes various studies in which lack of efficacies (LOEs) have been observed in dogs on macrocyclic lactone preventives relative to the United States of America. Some of these studies have been published in the peer-reviewed literature, others have appeared in various reports to the Center for Veterinary Medicine (CVM) of the Food and Drug Administration (FDA) of the USA as New Animal Drug Application (NADA) summaries, and one appeared as a letter to US veterinarians. This review also discusses reports relating to the potential problem of heartworm resistance in microfilariae and third-stage larvae, as well as molecular markers associated with resistance to macrocyclic lactones within Dirofilaria immitis. As more work is being done in this area of great concern relative to the protection of dogs from infection using this class of preventives, it seems timely to summarize what is known about heartworms, their potential resistance to treatment, and the means of selecting for resistance genes in populations of this helminth in the laboratory and in the field.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 3%
Malaysia 1 3%
United States 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 16%
Student > Bachelor 5 14%
Researcher 5 14%
Student > Ph. D. Student 4 11%
Other 4 11%
Other 13 35%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 13 35%
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 5 14%
Unspecified 4 11%
Chemistry 2 5%
Other 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2012.
All research outputs
#7,813,082
of 12,451,686 outputs
Outputs from Parasites & Vectors
#1,862
of 3,208 outputs
Outputs of similar age
#69,248
of 124,033 outputs
Outputs of similar age from Parasites & Vectors
#6
of 19 outputs
Altmetric has tracked 12,451,686 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,208 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,033 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.