Title |
Salvinorin A Reduces Mechanical Allodynia and Spinal Neuronal Hyperexcitability Induced by Peripheral Formalin Injection
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Published in |
Molecular Pain, January 2012
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DOI | 10.1186/1744-8069-8-60 |
Pubmed ID | |
Authors |
Francesca Guida, Livio Luongo, Gabriella Aviello, Enza Palazzo, Maria De Chiaro, Luisa Gatta, Serena Boccella, Ida Marabese, Jordan K Zjawiony, Raffaele Capasso, Angelo A Izzo, Vito de Novellis, Sabatino Maione |
Abstract |
Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode of action of SA on formalin-induced persistent pain in mice. Specifically, the SA effects on long-term behavioural dysfuctions and changes in neuronal activity occurring at spinal level, after single peripheral formalin injection, have been investigated. Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 19% |
Researcher | 8 | 17% |
Student > Bachelor | 5 | 10% |
Professor | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Other | 7 | 15% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 15% |
Neuroscience | 7 | 15% |
Chemistry | 5 | 10% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 9 | 19% |
Unknown | 10 | 21% |