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Salvinorin A Reduces Mechanical Allodynia and Spinal Neuronal Hyperexcitability Induced by Peripheral Formalin Injection

Overview of attention for article published in Molecular Pain, January 2012
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48 Mendeley
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Title
Salvinorin A Reduces Mechanical Allodynia and Spinal Neuronal Hyperexcitability Induced by Peripheral Formalin Injection
Published in
Molecular Pain, January 2012
DOI 10.1186/1744-8069-8-60
Pubmed ID
Authors

Francesca Guida, Livio Luongo, Gabriella Aviello, Enza Palazzo, Maria De Chiaro, Luisa Gatta, Serena Boccella, Ida Marabese, Jordan K Zjawiony, Raffaele Capasso, Angelo A Izzo, Vito de Novellis, Sabatino Maione

Abstract

Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode of action of SA on formalin-induced persistent pain in mice. Specifically, the SA effects on long-term behavioural dysfuctions and changes in neuronal activity occurring at spinal level, after single peripheral formalin injection, have been investigated. Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Researcher 8 17%
Student > Bachelor 5 10%
Professor 5 10%
Student > Doctoral Student 4 8%
Other 7 15%
Unknown 10 21%
Readers by discipline Count As %
Medicine and Dentistry 8 17%
Pharmacology, Toxicology and Pharmaceutical Science 7 15%
Neuroscience 7 15%
Chemistry 5 10%
Agricultural and Biological Sciences 2 4%
Other 9 19%
Unknown 10 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2012.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Molecular Pain
#447
of 669 outputs
Outputs of similar age
#199,372
of 250,101 outputs
Outputs of similar age from Molecular Pain
#36
of 47 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,101 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.