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Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

Overview of attention for article published in Cancer Cell, November 2010
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

Mentioned by

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4 tweeters

Citations

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103 Dimensions

Readers on

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84 Mendeley
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Title
Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer
Published in
Cancer Cell, November 2010
DOI 10.1016/j.ccr.2010.10.015
Pubmed ID
Authors

Ferdinandos Skoulidis, Liam D. Cassidy, Venkat Pisupati, Jon G. Jonasson, Hordur Bjarnason, Jorunn E. Eyfjord, Florian A. Karreth, Michael Lim, Lorraine M. Barber, Susan A. Clatworthy, Susan E. Davies, Kenneth P. Olive, David A. Tuveson, Ashok R. Venkitaraman

Abstract

Inherited heterozygous BRCA2 mutations predispose carriers to tissue-specific cancers, but somatic deletion of the wild-type allele is considered essential for carcinogenesis. We find in a murine model of familial pancreatic cancer that germline heterozygosity for a pathogenic Brca2 truncation suffices to promote pancreatic ductal adenocarcinomas (PDACs) driven by Kras(G12D), irrespective of Trp53 status. Unexpectedly, tumor cells retain a functional Brca2 allele. Correspondingly, three out of four PDACs from patients inheriting BRCA2(999del5) did not exhibit loss-of-heterozygosity (LOH). Three tumors from these patients displaying LOH were acinar carcinomas, which also developed only in mice with biallelic Brca2 inactivation. We suggest a revised model for tumor suppression by BRCA2 with implications for the therapeutic strategy targeting BRCA2 mutant cancer cells.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Australia 1 1%
France 1 1%
China 1 1%
United States 1 1%
Netherlands 1 1%
Unknown 77 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 32%
Researcher 22 26%
Professor > Associate Professor 11 13%
Student > Master 7 8%
Student > Bachelor 4 5%
Other 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 42%
Medicine and Dentistry 21 25%
Biochemistry, Genetics and Molecular Biology 19 23%
Unspecified 5 6%
Business, Management and Accounting 1 1%
Other 3 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2012.
All research outputs
#6,598,136
of 12,308,275 outputs
Outputs from Cancer Cell
#1,719
of 2,108 outputs
Outputs of similar age
#56,813
of 123,953 outputs
Outputs of similar age from Cancer Cell
#28
of 39 outputs
Altmetric has tracked 12,308,275 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,108 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,953 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.