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Widespread parainflammation in human cancer

Overview of attention for article published in Genome Biology (Online Edition), July 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
8 news outlets
blogs
2 blogs
twitter
40 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
97 Mendeley
citeulike
1 CiteULike
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Title
Widespread parainflammation in human cancer
Published in
Genome Biology (Online Edition), July 2016
DOI 10.1186/s13059-016-0995-z
Pubmed ID
Authors

Dvir Aran, Audrey Lasry, Adar Zinger, Moshe Biton, Eli Pikarsky, Asaf Hellman, Atul J. Butte, Yinon Ben-Neriah

Abstract

Chronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly promotes mouse gut tumorigenesis upon p53 loss. Here we explore the prevalence of parainflammation in human cancer and determine its relationship to certain molecular and clinical parameters affecting treatment and prognosis. We generated a transcriptome signature to identify parainflammation in many primary human tumors and carcinoma cell lines as distinct from their normal tissue counterparts and the tumor microenvironment and show that parainflammation-positive tumors are enriched for p53 mutations and associated with poor prognosis. Non-steroidal anti-inflammatory drug (NSAID) treatment suppresses parainflammation in both murine and human cancers, possibly explaining a protective effect of NSAIDs against cancer. We conclude that parainflammation, a low-grade form of inflammation, is widely prevalent in human cancer, particularly in cancer types commonly harboring p53 mutations. Our data suggest that parainflammation may be a driver for p53 mutagenesis and a guide for cancer prevention by NSAID treatment.

Twitter Demographics

The data shown below were collected from the profiles of 40 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 1%
Netherlands 1 1%
Japan 1 1%
Portugal 1 1%
Unknown 91 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 24%
Student > Ph. D. Student 22 23%
Other 7 7%
Professor 6 6%
Student > Bachelor 6 6%
Other 19 20%
Unknown 14 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 28%
Biochemistry, Genetics and Molecular Biology 24 25%
Medicine and Dentistry 14 14%
Immunology and Microbiology 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 7 7%
Unknown 19 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2019.
All research outputs
#232,209
of 16,272,302 outputs
Outputs from Genome Biology (Online Edition)
#171
of 3,453 outputs
Outputs of similar age
#6,567
of 263,318 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 2 outputs
Altmetric has tracked 16,272,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,453 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them