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Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing

Overview of attention for article published in PLoS ONE, September 2012
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Mentioned by

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1 tweeter

Citations

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18 Dimensions

Readers on

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45 Mendeley
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Title
Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing
Published in
PLoS ONE, September 2012
DOI 10.1371/journal.pone.0044263
Pubmed ID
Authors

Manuel Bañó-Polo, Carlos Baeza-Delgado, Mar Orzáez, Marc A. Marti-Renom, Concepción Abad, Ismael Mingarro

Abstract

The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices, often with a functional and/or structural role. Here, using as scaffold the hydrophobic TM domain of the model membrane protein glycophorin A (GpA), we address the consequences of replacing specific residues by ionizable amino acids on TM helix insertion and packing, both in detergent micelles and in biological membranes. Our findings demonstrate that ionizable residues are stably inserted in hydrophobic environments, and tolerated in the dimerization process when oriented toward the lipid face, emphasizing the complexity of protein-lipid interactions in biological membranes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Chile 1 2%
France 1 2%
India 1 2%
Spain 1 2%
United States 1 2%
Unknown 39 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 40%
Researcher 9 20%
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Professor 3 7%
Other 7 16%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 42%
Biochemistry, Genetics and Molecular Biology 17 38%
Chemistry 4 9%
Physics and Astronomy 2 4%
Computer Science 1 2%
Other 1 2%
Unknown 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2012.
All research outputs
#2,311,813
of 4,507,072 outputs
Outputs from PLoS ONE
#42,896
of 80,036 outputs
Outputs of similar age
#36,878
of 78,239 outputs
Outputs of similar age from PLoS ONE
#1,881
of 3,565 outputs
Altmetric has tracked 4,507,072 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 80,036 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,239 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,565 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.