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Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing

Overview of attention for article published in PLOS ONE, September 2012
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1 tweeter

Citations

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Title
Polar/Ionizable Residues in Transmembrane Segments: Effects on Helix-Helix Packing
Published in
PLOS ONE, September 2012
DOI 10.1371/journal.pone.0044263
Pubmed ID
Authors

Manuel Bañó-Polo, Carlos Baeza-Delgado, Mar Orzáez, Marc A. Marti-Renom, Concepción Abad, Ismael Mingarro

Abstract

The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices, often with a functional and/or structural role. Here, using as scaffold the hydrophobic TM domain of the model membrane protein glycophorin A (GpA), we address the consequences of replacing specific residues by ionizable amino acids on TM helix insertion and packing, both in detergent micelles and in biological membranes. Our findings demonstrate that ionizable residues are stably inserted in hydrophobic environments, and tolerated in the dimerization process when oriented toward the lipid face, emphasizing the complexity of protein-lipid interactions in biological membranes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Chile 1 2%
France 1 2%
India 1 2%
Spain 1 2%
United States 1 2%
Unknown 43 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 35%
Researcher 9 18%
Student > Bachelor 4 8%
Professor 3 6%
Student > Doctoral Student 3 6%
Other 11 22%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 41%
Biochemistry, Genetics and Molecular Biology 19 39%
Chemistry 5 10%
Computer Science 1 2%
Unspecified 1 2%
Other 2 4%
Unknown 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2012.
All research outputs
#13,722,695
of 20,587,020 outputs
Outputs from PLOS ONE
#115,459
of 177,689 outputs
Outputs of similar age
#91,134
of 147,075 outputs
Outputs of similar age from PLOS ONE
#2,354
of 3,681 outputs
Altmetric has tracked 20,587,020 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 177,689 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,075 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,681 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.