"sertraline inhibits SHMT1/2 activity and glycine uptake, leading to reduced net serine uptake and de novo serine synthesis, to prevent serine accumulation." https://t.co/C4cjghJk6d
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3,583 followers
https://t.co/3P4FKWidrb "Together, these results support that sertraline inhibits SHMT1/2 activity and glycine uptake, leading to reduced net serine uptake and de novo serine synthesis, to prevent serine accumulation."
3,583 followers
https://t.co/3P4FKWidrb "The strength of blocking both the serine into glycine interconversion and glycine uptake is what makes SHMT inhibitors more cytotoxic, explaining sertraline’s potent activity on MDA-MB-468 cells, as was previously also observed us
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https://t.co/3P4FKWidrb "Furthermore, measuring glycine uptake and secretion rates revealed that sertraline-treated MDA-MB-468 cells have the tendency to take up less glycine"