Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5

Overview of attention for article published in Frontiers in Cardiovascular Medicine, November 2020

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また、大動脈解離患者の平滑筋細胞ではKlf5の発現を誘導するFTOの高発現(Ang-II→FTO↑)が認められる。これを踏まえると、Ang-II (高血圧) → FTO↑ → Klf5↑ → miR-155↑ → 内皮バリア崩壊 → aortic dissection という発症メカニズムが予想されるかもしれない！ https://t.co/OwEkejz8hO

01 Aug 2021

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New Research: Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5: Background: Aortic dissecting aneurysm (ADA) represents an aortic remodeling disease with a high mortality rate. Fat mass and… https://t.co/fFwZiD0v

20 Nov 2020

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