↓ Skip to main content

Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells

Overview of attention for article published in BMC Complementary and Alternative Medicine, July 2012
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells
Published in
BMC Complementary and Alternative Medicine, July 2012
DOI 10.1186/1472-6882-12-89
Pubmed ID
Authors

Melody Saikali, Akram Ghantous, Racha Halawi, Salma N Talhouk, Najat A Saliba, Nadine Darwiche

Abstract

Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolated from Centaurea ainetensis, for their anti-tumor properties. We used the mouse epidermal JB6P + cells as a model for tumor promotion and cellular transformation. Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-κB transcription factors; therefore, we assessed how β-tan and Sal A modulate their signaling pathways in JB6P + cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 26%
Student > Master 4 21%
Professor > Associate Professor 3 16%
Student > Ph. D. Student 3 16%
Professor 2 11%
Other 1 5%
Unknown 1 5%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 21%
Agricultural and Biological Sciences 4 21%
Chemistry 4 21%
Medicine and Dentistry 3 16%
Immunology and Microbiology 1 5%
Other 2 11%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2012.
All research outputs
#9,906,035
of 12,373,180 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,741
of 2,511 outputs
Outputs of similar age
#90,583
of 127,622 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#33
of 34 outputs
Altmetric has tracked 12,373,180 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,511 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,622 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.