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TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1

Overview of attention for article published in Oncotarget, July 2016
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Mentioned by

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2 tweeters

Citations

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20 Dimensions

Readers on

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16 Mendeley
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Title
TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1
Published in
Oncotarget, July 2016
DOI 10.18632/oncotarget.10382
Pubmed ID
Authors

Yunhee Lee, Dongjoon Ko, Hye-Jin Min, Sol Bi Kim, Hye-Mi Ahn, Younghoon Lee, Semi Kim

Abstract

TMPRSS4 is a novel type II transmembrane serine protease found at the cell surface that is highly expressed in pancreatic, colon, and other cancer tissues. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, and metastasis. We also found that TMPRSS4 activates the transcription factor activating protein-1 (AP-1) to induce cancer cell invasion. Here, we explored TMPRSS4-mediated cellular functions and the underlying mechanisms. TMPRSS4 induced Slug, an epithelial-mesenchymal transition (EMT)-inducing transcription factor, and cyclin D1 through activation of AP-1, composed of c-Jun and activating transcription factor (ATF)-2, which resulted in enhanced invasion and proliferation of PC3 prostate cancer cells. In PC3 cells, not only c-Jun but also Slug was required for TMPRSS4-mediated proliferation and invasion. Interestingly, Slug induced phosphorylation of c-Jun and ATF-2 to activate AP-1 through upregulation of Axl, establishing a positive feedback loop between Slug and AP-1, and thus induced cyclin D1, leading to enhanced proliferation. Using data from The Cancer Genome Atlas, we found that Slug expression positively correlated with that of c-Jun and cyclin D1 in human prostate cancers. Expression of Slug was positively correlated with that of cyclin D1 in various cancer cell lines, whereas expression of other EMT-inducing transcription factors was not. This study demonstrates that TMPRSS4 modulates both invasion and proliferation via Slug and cyclin D1, which is a previously unrecognized pathway that may regulate metastasis and cancer progression.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Student > Master 3 19%
Student > Bachelor 1 6%
Professor 1 6%
Researcher 1 6%
Other 1 6%
Unknown 5 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 44%
Unspecified 1 6%
Computer Science 1 6%
Agricultural and Biological Sciences 1 6%
Unknown 6 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2016.
All research outputs
#4,000,111
of 8,029,085 outputs
Outputs from Oncotarget
#2,168
of 8,397 outputs
Outputs of similar age
#129,646
of 259,566 outputs
Outputs of similar age from Oncotarget
#33
of 65 outputs
Altmetric has tracked 8,029,085 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,397 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,566 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.