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Animal Cell Technology: From Target to Market

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Cover of 'Animal Cell Technology: From Target to Market'

Table of Contents

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    Book Overview
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    Chapter 1 In Vitro Testing of a New Substance with Anti-Tumor Activity on Mammalian Cells Using Flow Cytometry
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    Chapter 2 Destabilization of Green Fluorescent Protein by Substitution of Its Amino-Terminal Residue
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    Chapter 3 Anti-Tumor Activity of Noguchi Catalyser 21™, a Mineral Water Containing Natural Leaf Soil
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    Chapter 4 Fermented Milk, Kefram-Kefir Enhances Glucose Uptake into Insulin-Responsive Muscle Cells
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    Chapter 5 Optimization of Medium for M2 (Anti-Flag) Hybridoma Using Factorial Matrix Designs
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    Chapter 6 Neurite Outgrowth Promoting Substance from a Marine Alga, Sargassum Macrocarpum
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    Chapter 7 Neutralization of the Biological Activity of Glycosylated and Non-Glycosylated hGM-CSF by Monoclonal Antibodies
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    Chapter 8 High Cell Density Cultivation of Mast Cells in Fluidized-Bed and Fixed-Bed Bioreactors
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    Chapter 9 Over-Expression of Protein Kinase Bα Enhances Recombinant Protein Expression in Transient Systems
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    Chapter 10 100 Liter Transient Transfection
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    Chapter 11 Application of Alphavirus Vectors in Drug Discovery
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    Chapter 12 The Use of UCOE Vectors in Combination with a Preadapted Serum Free, Suspension Cell Line Allows for Rapid Production of Large Quantities of Protein
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    Chapter 13 Overexpression of a Transcription Factor to Maximize Glycoprotein Production in an Inducible Expression System
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    Chapter 14 Glucose Dehydrogenase as Detector Protein of Recombinant Fusion-Proteins Directly in SDS Gels
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    Chapter 15 Successful Transfection of Partially Purified DNA in the HEK293EBNA Cell Line for Transient Expression
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    Chapter 16 Capillary-Aided Cell Cloning
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    Chapter 17 The Comparative Study of Cultural and Productive Characteristics of Different Recombinant Cell Lines Producing Human Erythropoietin
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    Chapter 18 The Use of a C-FOS-GFP Reporter System for Monitoring Apoptosis of Animal Cells Induced by Exotoxins of Pseudomonas Aeruginosa
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    Chapter 19 High Performance Transient Expression in Mammalian Cells
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    Chapter 20 In 30 Days from Plasmid to Product: Expression of a Secreted Fusion Protein Using Hek293-EBNA Cells
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    Chapter 21 SF9 Cells Infection and Fuc-TIII Quality in Serum-Free and Serum-Containing Media
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    Chapter 22 Rapid Expression of Recombinant Proteins in Modified CHO Cells Using the Baculovirus System
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    Chapter 23 Recombinant Glycoprotein Production by CHO Cells in Low Protein Serum Free Medium
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    Chapter 24 Arginine Is a Limiting Essential Amino Acid in Batch Cultures of Recombinant Chinese Hamster Orvary Cells Producing Thrombopoietin
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    Chapter 25 Production of Recombinant Allergen Proder P 1 by CHO Cells Adapted to Grow in Serum-Free Suspension
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    Chapter 26 Pilot Scale Production and Purification of a Soluble E-Selectin-IgG Chimeric Protein
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    Chapter 27 Environmental Effects on Cell Physiology and Metabolism: Response to Elevated pC02
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    Chapter 28 Improved Dual-Regulated Expression Systems for Independent Control of Two Different Transgenes
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    Chapter 29 Metabolic Flux Analysis in Mammalian Cells — Network Modelling as an Example for Metabolic Design in Recombinant BHK Cells
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    Chapter 30 Assessment of Keratin Expression and Xenobiotic Metabolism in Cultured Normal and Transformed Human Oral Keratinocytes
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    Chapter 31 Regulation of Cell Cycle and Productivity in NS0 Cells by the Over-Expression of p21CIP1
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    Chapter 32 Loss of Productivity of a Transfectoma in Long-Term Culture: Recovery of Expression
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    Chapter 33 Adaptation and Selection of NSO Myeloma Cell Lines Producing Recombinant Monoclonal Antibodies in Protein-Free Medium
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    Chapter 34 Specific Effects of Synthetic Oligopeptides in Animal Cell Culture
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    Chapter 35 Differential Enhancement of Monoclonal Antibody Production by Retinoids in Human Hybridomas
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    Chapter 36 Regulation Mechanisms of Antibody Production from Human PBMC Immunized in vitro
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    Chapter 37 Influences of Glutamine Concentration on Cellular Metabolism in Continuous Culture of Hybridoma
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    Chapter 38 Study of NS0 Cell Line Metabolism in Lipid Supplemented Protein Free Media
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    Chapter 39 Metabolic Shifts in Hybridoma Cells Utilising Wheat Peptides
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    Chapter 40 Bi-Phasic Culture Strategies Based on Medium Formulation: Substitution of Glucose by Galactose in CHO Culture
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    Chapter 41 New Advanced Protein-Free, Animal Component-Free Medium for Recombinant Protein Expression in Adherent CHO Cell Cultures
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    Chapter 42 Na+ Is Responsible for Intra-Run Variations of Specific Productivity of CHO Cell Lines Producing Human Anti Rh D IgG in Bioreactors
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    Chapter 43 The Influence of pH on Cell Growth and Specific Productivity of Two CHO Cell Lines Producing Human Anti Rh D IgG
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    Chapter 44 The Modification of a Serum-Free Media Formulation for the Production of Reovirus and the Growth of Vero, MRC-5, MDCK and BHK Cell Lines
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    Chapter 45 The Role of Vitamins in Cell Culture Media
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    Chapter 46 Effect of Sodium Butyrate on Glycosylation of Recombinant Erythropoietin
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    Chapter 47 Identification of Betacellulin as a Major Growth Factor in Foetal Bovine Serum and Development of a Recombinant Betacellulin Analogue for Use in Serum-Free Cell Culture
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    Chapter 48 Monitoring Growth and Death of Vero Cells Cultivated in Bioreactor with Serum-Containing and Serum-Free Media
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    Chapter 49 Effects of a Rice Protein Hydrolysate on Growth of CHO Cells and Production of Human Interferon-γ in a Serum-Free Medium
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    Chapter 50 Suppressive Effect of Electrolyzed-Reduced Water on the Growth of Cancer Cells and Microorganisms
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    Chapter 51 Transient Bcl-x L Overexpression Has Different Effects on Protein Production in Various CHO-Derived Cell Lines
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    Chapter 52 Proteolytic Potential during Batch Cultivation in Serum Free Media of an IFN-γ Producing CHO Cell Line
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    Chapter 53 Genetic Strategies for Apoptosis Protection of Hybridoma Cells Based on Overexpression of Cellular and Viral Proteins
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    Chapter 54 Modulation of Cell Proliferation by Metabolic Engineering
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    Chapter 55 S-Phase Synchronized CHO Cells Show Elevated Transfection Efficiency and Expression Using CA/PO4
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    Chapter 56 Expression of Yeast Pyruvate Carboxylate in hGM-CSF-Producing CHO Cells
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    Chapter 57 The Influence of Culture Conditions on the Development of Trans-Epithelial Electrical Resistance (TEER) and the Junctional Complex of MDCK Cells
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    Chapter 58 Bioreactor for Pharmaceutical Screening Generally Applicable for Primary Cells
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    Chapter 59 Increasing Population of Amniotic Epithelial Cells
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    Chapter 60 Evaluation of the Biological Activity of Some Hormones, Growth Factors and Drugs on Cultured Cells, Isolated from Animal and Human Reproductive Organs
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    Chapter 61 Cultivation of Human Articular Chondrocytes for Autologous Transplantation
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    Chapter 62 A Cell Culture System from the Eye Stalk of Penaeus Indicus
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    Chapter 63 Cytotoxicity of Pyrethroid Insecticides in Rat Hepatoma-Derived Fa32 Cells
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    Chapter 64 New Technologies for Automated Cell Counting Based on Optical Image Analysis “The Cellscreen”
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    Chapter 65 Application of an Acceleration-Stat to Study Insect Cell Metabolism
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    Chapter 66 Factorial Design and Analysis for Rapid Development of an Antibody Production Process in CHO Cells
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    Chapter 67 Development of a Large Scale Process for the Production of Recombinant Truncated Factor VIII in CHO Cells under Cell Growth Arrest Conditions
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    Chapter 68 Continuous Perfusion versus Discontinuous Fed-Batch
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    Chapter 69 The Use of Hydrocyclones for Mammalian Cell Retention in Perfusion Bioreactors
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    Chapter 70 High Throughput Cultivation of Animal Cells Using Shaken Microplate Techniques
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    Chapter 71 Continuous Isolation of rFVIII from Mammalian Cell Culture
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    Chapter 72 Sodium Butyrate Treatment: A Study of Critical Parameters Using CHO Cell Lines Expressing the Green Fluorescent Protein
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    Chapter 73 Development of a Robust Protocol for the Production of Recombinant Proteins up to 20-L Scale Using BEVS
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    Chapter 74 Optimising the Production of a Nuclear Receptor in SF9 Cells Using Response Surface Analysis
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    Chapter 75 Growth of High-Five™ Cells on Cultispher-S Microbarriers
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    Chapter 76 Catching the Wave: The BEVS and the Biowave
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    Chapter 77 Physiology of Insect Cells Cultured in a New Serum-Free Medium
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    Chapter 78 Characterisation and Evaluation of a New Screening System for Animal Cell Culture
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    Chapter 79 Development of Bioprocess Concepts on Vaccine Production: Influenza Virus as an Example
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    Chapter 80 Assay of Serum and Animal Protein Free Media for the Production of a Veterinary Rabies Vaccine by BHK-21 Cells
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    Chapter 81 Cell Cultivation System on the Basis of Porous Ceramic for the Production of Virus-Like Particles
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    Chapter 82 Influence of Cell Culture Media on Adhesion of Animal Cells on Microcarriers
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    Chapter 83 Comparison of Three Different Serum Free Media: Scale up of a Semi-Continuous CHO Cell Process in an Industrial Application
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    Chapter 84 Use of Plant Peptone-Containing Serum-Free Media for the Cultivation of CHO Cells in Suspension and on Microcarriers
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    Chapter 85 Application of Protein-Free Cell Culture Media for the Manufacturing of Biopharmaceuticals
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    Chapter 86 Fluid Bed Granulation as an Alternative to Milled Powders to Improve Performance of Dry-Form, Serum-Free Nutrient Media
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    Chapter 87 NanoColloids: A New Method for Solubilization of Lipophilic Substances Used in Cell Culture
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    Chapter 88 Development and Validation of a Novel Process for the Production of Powdered Cell Culture Media
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    Chapter 89 Separation of Mammalian Cells Using a Specially Designed Rotating Disc Filter
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    Chapter 90 Comparison of Fluidised Bed and Ultrasonic Cell-Retention Systems for High Cell Density Mammalian Cell Culture
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    Chapter 91 Ultrasonic Cell Separation — Production of Monoclonal Antibodies in Continuous Perfusion Cultures
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    Chapter 92 Increased Production Yields of Native Interferon-γ in Membrane Bioreactors by Continuous Harvest
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    Chapter 93 Production of rhEPO in Hollow Fibers’ Bioreactor
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    Chapter 94 Production of rhEPO under Variants of Cultivation Media
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    Chapter 95 Solution to the high Dissolved CO2 Problem in High-Density Perfusion Culture of Mammalian Cells
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    Chapter 96 Perfusion Cell Culture in Disposable Bioreactors
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    Chapter 97 Process Development in a Packed Bed Bioreactor
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    Chapter 98 The Art & Science of Micro-Sparging in High-Density Perfusion Cultures of Animal Cells
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    Chapter 99 Culture of the CB.Hep-1 Hybridoma Using Different in vitro Systems
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    Chapter 100 Selection of Suitable Anti-rHBsAg Mabs for in vitro Production
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    Chapter 101 Reorganizing of Monoclonal Antibodies Process in the Era of Human Genome Cloning
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    Chapter 102 Production of a Highly Pure Mab from Cell-Pharm System CP-2500
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    Chapter 103 How Does Protein Free Medium Turbodoma™ HP-I Perform in Mouse Hybridoma Cultures in Different Culture Systems?
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    Chapter 104 Effect of Seed Cell Density on Specific Growth Rate Using CHO Cells as Model
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    Chapter 105 Adaptation and Growth Kinetics of the Universal Host CHO Cell Lines in Serum-Free Medium
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    Chapter 106 Process Development for Functional Membrane Receptor Production in Mammalian Cells
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    Chapter 107 Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells
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    Chapter 108 The One Step Inoculation Concept: A New Seed-Train Expansion for Recombinant Mammalian Cell Lines
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    Chapter 109 In-Situ Microscopy for On-Line and In-Line Monitoring of Cell Populations in Bioreactors
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    Chapter 110 Measurement of the Viable Cell Density: Validation and Integration of On-Line and Off-Line Capacitance Biomass Monitors for Cell Culture Processes
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    Chapter 111 Robot Automation of Sampling and Sample Management during Cultivation of Mammalian Cells in Pilot Scale
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    Chapter 112 Rapid Estimation of Human Monoclonal Antibody (IgG4) Concentration in Cell Culture Supernatants
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    Chapter 113 Use of Ion-Exchange Membrane Adsorbers for Production of Biopharmaceuticals
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    Chapter 114 Pharmaceuticals Produced by Biotechnology: Quality and Safety Issues
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    Chapter 115 Factory IQ/OQ, A New Approach for Streamlining Validation of Cell Culture Equipment
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    Chapter 116 Critical Issues for the Use of Tangential Flow Filtration Systems for Cell Harvesting Applications
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    Chapter 117 A General Method for the On-Line RT-PCR Detection of Retrovirus Contamination in Cell Lines Used for Protein and Viral Vector Production
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    Chapter 118 Novel Assay for Protein Impurities in Biopharmaceuticals Based on Fluorescence Intensity Distribution Analysis (FIDA)
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    Chapter 119 Development of Mammalian Cell Bioreactor Processes
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    Chapter 120 Development of Microgranulated Form of the Live Measles Vaccine
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    Chapter 121 Bioprocess Development for the Cultivation of Human T-Lymphocytes
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    Chapter 122 Adenovirally Modified Dendritic Cells for Immunotherapy: From Basic Development to Clinical Application
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    Chapter 123 GMP Compliant Expansion of Hematopoietic Stem Cells (CD34+) Selected from Cord Blood for a Phase I Cell Therapy Trial
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    Chapter 124 Multi-Plasmid Vaccines for HIV-1: Issues and Advancements
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    Chapter 125 Continuous Retroviral Vector Production in a Perfusion Bioreactor System
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    Chapter 126 Monolayer and Suspension Cultures of HEK 293 Cells for Recombinant Adenovirus Production for Gene Therapy: Effect of “Cell Passage Number”
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    Chapter 127 Possible Strategies for the Production of Viral Vector: The Role of Engineering Design
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    Chapter 128 Establishing Novel Hepatoma Cell Line for Bioartificial Liver
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    Chapter 129 An Improved Oxygenation Hollow Fiber Bioreactor for the Cultivation of Liver Cells
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    Chapter 130 Medium for Gene Therapy: Improved Protein-Free Media for Growth and Production of Viral Vectors for Use in Gene Therapy
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    Chapter 131 Induction of a T Helper Cell Response against the Tumor Associated Antigen Her-2 Using Monocyte-Derived Dendritic Cells
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    Chapter 132 Cultivation of Human HCMV Specific Lymphocytes — An Example for Adoptive Immunotherapy
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    Chapter 133 Application of hTERT Promoter to Cancer Therapy
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    Chapter 134 Establishment of a Genetic System to Coordinate Feeder Cell Growth in Cocultures with Primary Cells
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    Chapter 135 Construction and Operation of a Bioreactor for Three-Dimensional Cartilage-Implants
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    Chapter 136 Tissue Engineering of Meniscal Cartilage
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    Chapter 137 Anti-Oxidative Water Improves Diabetes
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    Chapter 138 Effect of Transfection-Induced Changes in Expression of Insulin-Like Growth Factor Binding Proteins on Secretory Activity and Responses of Ovarian Cell Cultures
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    Chapter 139 Cultivation of Primary Osteogenic Cells in Serum-Reduced or Serum-Free Culture Media: Attachment, Proliferation and Differentiation
Attention for Chapter 63: Cytotoxicity of Pyrethroid Insecticides in Rat Hepatoma-Derived Fa32 Cells
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Chapter title
Cytotoxicity of Pyrethroid Insecticides in Rat Hepatoma-Derived Fa32 Cells
Chapter number 63
Book title
Animal Cell Technology: From Target to Market
Published by
Springer Netherlands, January 2001
DOI 10.1007/978-94-010-0369-8_63
Book ISBNs
978-9-40-103897-3, 978-9-40-100369-8
Authors

P. J. Dierickx, C. Smit, E. M. Scheers

Editors

Dr Elisabeth Lindner-Olsson, Ms Nathalie Chatzissavidou, Dr Elke Lüllau

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The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 100%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 100%