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Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo

Overview of attention for article published in Nanomedicine: Nanotechnology, Biology and Medicine, November 2016
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2 tweeters

Citations

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45 Dimensions

Readers on

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45 Mendeley
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Title
Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
Published in
Nanomedicine: Nanotechnology, Biology and Medicine, November 2016
DOI 10.1016/j.nano.2016.06.014
Pubmed ID
Authors

James C. Evans, Meenakshi Malhotra, Jianfeng Guo, Joseph P. O'Shea, Karen Hanrahan, Amanda O'Neill, William D. Landry, Brendan T. Griffin, Raphael Darcy, R. William Watson, Caitriona M. O'Driscoll

Abstract

In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Targeted formulations showed increased uptake, relative to untargeted controls, in two prostate cancer cell lines expressing PSMA (VCaP and LNCaP). Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (p<0.001) Relative to untreated controls, folate-targeted nanoparticles significantly reduced the levels of RelA mRNA in VCaP and LNCaP cells by 44% and 22% respectively (p<0.001). In contrast there was no significant reduction in RelA mRNA in these cell lines by untargeted complexes. Pharmacokinetic (PK) data indicated that the incorporation of PEG into the formulation increased the circulation time of siRNA 8-fold. This study highlights the ability of incorporating a folate ligand into CD.siRNA nanoparticles to allow for targeted delivery of siRNA to prostate cancer cells via the PSMA.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 7 16%
Student > Ph. D. Student 6 13%
Student > Master 6 13%
Researcher 5 11%
Other 4 9%
Other 10 22%
Unknown 7 16%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 9 20%
Biochemistry, Genetics and Molecular Biology 6 13%
Chemistry 5 11%
Medicine and Dentistry 4 9%
Materials Science 3 7%
Other 9 20%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2016.
All research outputs
#9,653,754
of 12,577,171 outputs
Outputs from Nanomedicine: Nanotechnology, Biology and Medicine
#588
of 1,026 outputs
Outputs of similar age
#165,070
of 257,708 outputs
Outputs of similar age from Nanomedicine: Nanotechnology, Biology and Medicine
#33
of 95 outputs
Altmetric has tracked 12,577,171 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,026 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,708 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.