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Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon

Overview of attention for article published in Pharmacological Reports, October 2016
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Title
Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon
Published in
Pharmacological Reports, October 2016
DOI 10.1016/j.pharep.2016.05.009
Pubmed ID
Authors

Marek Krzystanek, Katarzyna Bogus, Artur Pałasz, Anna Wiaderkiewicz, Łukasz Filipczyk, Ewa Rojczyk, John Worthington, Ryszard Wiaderkiewicz

Abstract

This study aimed to evaluate the effect of extended olanzapine, clozapine and haloperidol administration on NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. To explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was performed. Interestingly, all neuroleptics caused a downregulation of NMDA-R subunit expression in the thalamus but increased the level of NR1 in the hypothalamus. Olanzapine upregulated hypothalamic NR2A expression, while clozapine and haloperidol decreased hypothalamic levels. We observed no significant changes in NR2B immunoreactivity. None of the studied medications had significant influence on NMDA-R subunit expression in the neocortex. Neuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico-striato-thalamo-cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 1 25%
Professor > Associate Professor 1 25%
Student > Bachelor 1 25%
Unknown 1 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 25%
Biochemistry, Genetics and Molecular Biology 1 25%
Neuroscience 1 25%
Unknown 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2016.
All research outputs
#12,460,950
of 14,089,795 outputs
Outputs from Pharmacological Reports
#395
of 560 outputs
Outputs of similar age
#217,510
of 260,146 outputs
Outputs of similar age from Pharmacological Reports
#13
of 18 outputs
Altmetric has tracked 14,089,795 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 560 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.