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Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung

Overview of attention for article published in PLoS ONE, September 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
facebook
2 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
30 Mendeley
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Title
Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung
Published in
PLoS ONE, September 2012
DOI 10.1371/journal.pone.0045667
Pubmed ID
Authors

Laura P. Hale, Erin Potts Kant, Paula K. Greer, W. Michael Foster

Abstract

The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pathogen exposure, increased exposure to inhaled pollutants, and changes in diet. Although iron is well-known to participate in critical biologic processes such as oxygen transport, energy generation, and host defense, iron deficiency remains common in the United States and world-wide. The purpose of these studies was to determine how dietary iron supplementation affected the severity of allergic inflammation in the lungs, using a classic model of IgE-mediated allergy in mice. Results showed that mice fed an iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, eosinophil infiltration, and production of pro-inflammatory cytokines, compared with control mice on an unsupplemented diet that generated mild iron deficiency but not anemia. In vitro, iron supplementation decreased mast cell granule content, IgE-triggered degranulation, and production of pro-inflammatory cytokines post-degranulation. Taken together, these studies show that iron supplementation can decrease the severity of allergic inflammation in the lung, potentially via multiple mechanisms that affect mast cell activity. Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Romania 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 27%
Researcher 3 10%
Student > Ph. D. Student 3 10%
Other 2 7%
Student > Master 2 7%
Other 6 20%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 12 40%
Agricultural and Biological Sciences 2 7%
Social Sciences 2 7%
Immunology and Microbiology 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 13%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2016.
All research outputs
#1,160,303
of 12,088,621 outputs
Outputs from PLoS ONE
#20,198
of 132,964 outputs
Outputs of similar age
#11,461
of 119,250 outputs
Outputs of similar age from PLoS ONE
#452
of 3,658 outputs
Altmetric has tracked 12,088,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132,964 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,250 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 3,658 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.