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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mutant dynactin in motor neuron disease
|
|---|---|
| Published in |
Nature Genetics, March 2003
|
| DOI | 10.1038/ng1123 |
| Pubmed ID | |
| Authors |
Imke Puls, Catherine Jonnakuty, Bernadette H. LaMonte, Erika L.F. Holzbaur, Mariko Tokito, Eric Mann, Mary Kay Floeter, Kimberly Bidus, Dennis Drayna, Shin J. Oh, Robert H. Brown, Christy L. Ludlow, Kenneth H. Fischbeck |
| Abstract |
Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. Mutation analysis of a gene in this interval that encodes the largest subunit of the axonal transport protein dynactin showed a single base-pair change resulting in an amino-acid substitution that is predicted to distort the folding of dynactin's microtubule-binding domain. Binding assays show decreased binding of the mutant protein to microtubules. Our results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 462 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 2 | <1% |
| France | 2 | <1% |
| Hungary | 2 | <1% |
| Germany | 1 | <1% |
| Egypt | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Guatemala | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 447 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 108 | 23% |
| Researcher | 62 | 13% |
| Student > Master | 56 | 12% |
| Student > Bachelor | 56 | 12% |
| Student > Doctoral Student | 23 | 5% |
| Other | 79 | 17% |
| Unknown | 78 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 140 | 30% |
| Neuroscience | 72 | 16% |
| Biochemistry, Genetics and Molecular Biology | 63 | 14% |
| Medicine and Dentistry | 59 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
| Other | 21 | 5% |
| Unknown | 100 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2015.
All research outputs
#2,769,276
of 22,679,690 outputs
Outputs from Nature Genetics
#3,166
of 7,175 outputs
Outputs of similar age
#4,059
of 48,893 outputs
Outputs of similar age from Nature Genetics
#12
of 63 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,175 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 48,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.