Title |
Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study
|
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Published in |
BMC Infectious Diseases, April 2010
|
DOI | 10.1186/1471-2334-10-94 |
Pubmed ID | |
Authors |
Amy B Howell, Henry Botto, Christophe Combescure, Anne-Béatrice Blanc-Potard, Lluis Gausa, Tetsuro Matsumoto, Peter Tenke, Albert Sotto, Jean-Philippe Lavigne |
Abstract |
Ingestion of cranberry (Vaccinium macrocarpon Ait.) has traditionally been utilized for prevention of urinary tract infections. The proanthocyanidins (PACs) in cranberry, in particular the A-type linkages have been implicated as important inhibitors of primarily P-fimbriated E. coli adhesion to uroepithelial cells. Additional experiments were required to investigate the persistence in urine samples over a broader time period, to determine the most effective dose per day and to determine if the urinary anti-adhesion effect following cranberry is detected within volunteers of different origins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Thailand | 2 | 40% |
United States | 1 | 20% |
Venezuela, Bolivarian Republic of | 1 | 20% |
Brazil | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Members of the public | 2 | 40% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Spain | 2 | <1% |
Panama | 1 | <1% |
Egypt | 1 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 281 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 43 | 15% |
Student > Bachelor | 37 | 13% |
Student > Master | 36 | 12% |
Other | 28 | 10% |
Student > Ph. D. Student | 25 | 9% |
Other | 52 | 18% |
Unknown | 69 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 60 | 21% |
Agricultural and Biological Sciences | 53 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 22 | 8% |
Biochemistry, Genetics and Molecular Biology | 20 | 7% |
Chemistry | 13 | 4% |
Other | 45 | 16% |
Unknown | 77 | 27% |