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Epidemiological risk factors for adult dengue in Singapore: an 8-year nested test negative case control study

Overview of attention for article published in BMC Infectious Diseases, July 2016
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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1 policy source
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Citations

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23 Dimensions

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Title
Epidemiological risk factors for adult dengue in Singapore: an 8-year nested test negative case control study
Published in
BMC Infectious Diseases, July 2016
DOI 10.1186/s12879-016-1662-4
Pubmed ID
Authors

Chee Fu Yung, Siew Pang Chan, Tun Linn Thein, Siaw Ching Chai, Yee Sin Leo

Abstract

Understanding changes in the ecology and epidemiology of dengue is important to ensure resource intensive control programmes are targeted effectively as well as to inform future dengue vaccination strategies. We analyzed data from a multicentre longitudinal prospective study of fever in adults using a nested test negative case control approach to identify epidemiological risk factors for dengue disease in Singapore. From April 2005 to February 2013, adult patients presenting with fever within 72 h at selected public primary healthcare clinics and a tertiary hospital in Singapore were recruited. Acute and convalescent blood samples were collected and used to diagnose dengue using both PCR and serology methods. A dengue case was defined as having a positive RT-PCR result for DENV OR evidence of serological conversion between acute and convalescent blood samples. Similarly, controls were chosen from patients in the cohort who tested negative for dengue using the same laboratory methods. The host epidemiological factors which increased the likelihood of dengue disease amongst adults in Singapore were those aged between 21 and 40 years old (2 fold increase) while in contrast, Malay ethnicity was protective (OR 0.57, 95%CI 0.35 to 0.91) against dengue disease. Spatial factors which increased the odds of acquiring dengue was residing at a foreign workers dormitory or hostel (OR 3.25, 95 % CI 1.84 to 5.73) while individuals living in the North-West region of the country were less likely to get dengue (OR 0.50, 95%CI 0.29 to 0.86). Other factors such as gender, whether one primarily works indoors or outdoors, general dwelling type or floor, the type of transportation one uses to work, travel history, as well as self-reported history of mosquito bite or household dengue/fever were not useful in helping to inform a diagnosis of dengue. We have demonstrated a test negative study design to better understand the epidemiological risk factors of adult dengue over multiple seasons. We were able to discount other previously speculated factors such as gender, whether one primarily works indoors or outdoors, dwelling floor in a building and the use of public transportation as having no effect on one's risk of getting dengue.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 118 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 20%
Researcher 13 11%
Student > Bachelor 13 11%
Student > Ph. D. Student 10 8%
Other 8 7%
Other 17 14%
Unknown 34 29%
Readers by discipline Count As %
Medicine and Dentistry 32 27%
Nursing and Health Professions 10 8%
Agricultural and Biological Sciences 9 8%
Biochemistry, Genetics and Molecular Biology 4 3%
Environmental Science 3 3%
Other 14 12%
Unknown 47 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2020.
All research outputs
#7,722,838
of 24,778,793 outputs
Outputs from BMC Infectious Diseases
#2,561
of 8,320 outputs
Outputs of similar age
#120,323
of 362,758 outputs
Outputs of similar age from BMC Infectious Diseases
#64
of 195 outputs
Altmetric has tracked 24,778,793 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 8,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,758 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 195 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.