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Behavioral Neurobiology of Chronic Pain

Overview of attention for book
Attention for Chapter 302: Neurobiology of Stress-Induced Hyperalgesia.
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Chapter title
Neurobiology of Stress-Induced Hyperalgesia.
Chapter number 302
Book title
Behavioral Neurobiology of Chronic Pain
Published in
Current topics in behavioral neurosciences, May 2014
DOI 10.1007/7854_2014_302
Pubmed ID
Book ISBNs
978-3-66-245093-2, 978-3-66-245094-9

Weredeselam M. Olango, David P. Finn


Bradley K. Taylor, David P. Finn


The intensity and severity of perceived pain does not correlate consistently with the degree of peripheral or central nervous system tissue damage or with the intensity of primary afferent or spinal nociceptive neurone activity. In this respect, the modulation of pain by emotion and context is now widely recognized. In particular, stress, fear and anxiety exert potent, but complex, modulatory influences on pain. Stress can either suppress pain (stress-induced analgesia) or exacerbate it (stress-induced hyperalgesia; SIH) depending on the nature, duration and intensity of the stressor. Herein, we review the methods and models used to study the phenomenon of SIH in rodents and humans and then present a detailed discussion of our current understanding of neural substrates and neurobiological mechanisms. The review provides perspectives and challenges for the current and future treatment of pain and the co-morbidity of pain with stress-related psychiatric disorders including anxiety and depression.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 30%
Student > Master 7 16%
Student > Bachelor 6 14%
Student > Doctoral Student 3 7%
Professor > Associate Professor 3 7%
Other 10 23%
Unknown 2 5%
Readers by discipline Count As %
Neuroscience 11 25%
Psychology 9 20%
Medicine and Dentistry 6 14%
Biochemistry, Genetics and Molecular Biology 5 11%
Nursing and Health Professions 4 9%
Other 5 11%
Unknown 4 9%