Title |
Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age
|
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Published in |
BMC Ecology and Evolution, June 2012
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DOI | 10.1186/1471-2148-12-99 |
Pubmed ID | |
Authors |
Like Fokkens, Paulien Hogeweg, Berend Snel |
Abstract |
The study of biological networks and how they have evolved is fundamental to our understanding of the cell. By investigating how proteins of different ages are connected in the protein interaction network, one can infer how that network has expanded in evolution, without the need for explicit reconstruction of ancestral networks. Studies that implement this approach show that proteins are often connected to proteins of a similar age, suggesting a simultaneous emergence of interacting proteins. There are several theories explaining this phenomenon, but despite the importance of gene duplication in genome evolution, none consider protein family dynamics as a contributing factor. |
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Demographic breakdown
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Mendeley readers
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Student > Ph. D. Student | 7 | 25% |
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Mathematics | 1 | 4% |
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Other | 1 | 4% |
Unknown | 1 | 4% |