↓ Skip to main content

Effector-Triggered Immune Response in Arabidopsis thaliana Is a Quantitative Trait

Overview of attention for article published in Genetics, September 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
24 X users

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
78 Mendeley
Title
Effector-Triggered Immune Response in Arabidopsis thaliana Is a Quantitative Trait
Published in
Genetics, September 2016
DOI 10.1534/genetics.116.190678
Pubmed ID
Authors

Michail Iakovidis, Paulo J. P. L. Teixeira, Moises Exposito-Alonso, Matthew G. Cowper, Theresa F. Law, Qingli Liu, Minh Chau Vu, Troy Minh Dang, Jason A. Corwin, Detlef Weigel, Jeffery L. Dangl, Sarah R. Grant

Abstract

We identified loci responsible for natural variation in Arabidopsis thaliana (Arabidopsis) responses to a bacterial pathogen virulence factor, HopAM1. HopAM1 is a type III effector protein secreted by the virulent Pseudomonas syringae strain Pto DC3000. Delivery of HopAM1 from disarmed Pseudomonas strains leads to local cell death, meristem chlorosis, or both, with varying intensities in different Arabidopsis accessions. These phenotypes are not associated with differences in bacterial growth restriction. We treated the two phenotypes as quantitative traits to identify host loci controlling responses to HopAM1. Genome Wide Association (GWA) of 64 Arabidopsis accessions identified independent variants highly correlated with response to each phenotype. Quantitative Trait Locus (QTL) mapping in a recombinant inbred population between Bur-0 and Col-0 accessions revealed genetic linkage to regions distinct from the top GWA hits. Two major QTL associated with HopAM1-induced cell death were also associated with HopAM1-induced chlorosis. HopAM1-induced changes in Arabidopsis gene expression showed that rapid HopAM1-dependent cell death in Bur-0 is correlated with effector-triggered immune responses. Studies of the effect of mutations in known plant immune system genes showed, surprisingly, that both cell death and chlorosis phenotypes are enhanced by loss of EDS1, a regulatory hub in the plant immune signaling network. Our results reveal complex genetic architecture for response to this particular type III virulence effector, in contrast to the typical monogenic control of cell death and disease resistance triggered by most type III effectors.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 77 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 23%
Student > Master 14 18%
Researcher 11 14%
Student > Bachelor 8 10%
Other 5 6%
Other 8 10%
Unknown 14 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 55%
Biochemistry, Genetics and Molecular Biology 22 28%
Nursing and Health Professions 1 1%
Unknown 12 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2016.
All research outputs
#2,614,440
of 25,373,627 outputs
Outputs from Genetics
#903
of 7,400 outputs
Outputs of similar age
#43,971
of 348,359 outputs
Outputs of similar age from Genetics
#27
of 94 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,400 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.