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Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer

Overview of attention for article published in Cochrane database of systematic reviews, August 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
7 Mendeley
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Title
Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer
Published in
Cochrane database of systematic reviews, August 2012
DOI 10.1002/14651858.cd007814.pub2
Pubmed ID
Authors

Sanjeev Deva, Michael Jameson

Abstract

Anecdotal reports of tumour regression with histamine type 2 receptor antagonists (H(2)RAs) have lead to a series of trials with this class of drug as adjuvant therapy to try and improve outcomes in patients with resected colorectal cancers. There was a plausible scientific rationale suggesting merit in this strategy. This included improved immune surveillance (by way of increasing tumour infiltrating lymphocytes), inhibiting the direct proliferative effect of histamine as a growth factor for colorectal cancer and, in the case of cimetidine, inhibiting endothelial expression of E-selectin (a cell adhesion molecule thought to be critical for metastatic spread).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 171%
Student > Master 9 129%
Student > Ph. D. Student 5 71%
Student > Bachelor 4 57%
Other 3 43%
Other 6 86%
Readers by discipline Count As %
Medicine and Dentistry 24 343%
Nursing and Health Professions 4 57%
Immunology and Microbiology 2 29%
Engineering 2 29%
Economics, Econometrics and Finance 2 29%
Other 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2015.
All research outputs
#3,113,737
of 12,527,093 outputs
Outputs from Cochrane database of systematic reviews
#5,354
of 8,923 outputs
Outputs of similar age
#29,187
of 127,957 outputs
Outputs of similar age from Cochrane database of systematic reviews
#36
of 87 outputs
Altmetric has tracked 12,527,093 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 8,923 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.