Title |
Demonstration of Blood Pressure-Independent Noninfarct Myocardial Fibrosis in Primary Aldosteronism
|
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Published in |
Circulation: Cardiovascular Imaging, September 2012
|
DOI | 10.1161/circimaging.112.974576 |
Pubmed ID | |
Authors |
E. Marie Freel, Patrick B. Mark, Robin A.P. Weir, Emily P. McQuarrie, Karen Allan, Henry J. Dargie, John D. McClure, Alan G. Jardine, Eleanor Davies, John M.C. Connell |
Abstract |
Primary aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone and sodium leads to cardiac fibrosis and hypertrophy in humans and animals possibly mediated by inflammation and oxidative stress. We aimed to clarify the effects of aldosterone excess on myocardial structure and composition in human subjects with PA and essential hypertension using contrast-enhanced cardiac magnetic resonance imaging as well as explore the mechanistic basis for any observed differences. |
X Demographics
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Unknown | 2 | 67% |
Demographic breakdown
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Mendeley readers
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