Title |
Can exercise ameliorate treatment toxicity during the initial phase of testosterone deprivation in prostate cancer patients? Is this more effective than delayed rehabilitation?
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Published in |
BMC Cancer, September 2012
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DOI | 10.1186/1471-2407-12-432 |
Pubmed ID | |
Authors |
Robert U Newton, Dennis R Taaffe, Nigel Spry, Prue Cormie, Suzanne K Chambers, Robert A Gardiner, David HK Shum, David Joseph, Daniel A Galvão |
Abstract |
There has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass and increased skeletal fractures compounded with rapid metabolic alterations, including increased body fat, reduced lean mass, insulin resistance and negative lipoprotein profile, increased incidence of cardiovascular and metabolic morbidity, greater distress and reduced quality of life. Numerous research studies have demonstrated certain exercise prescriptions to be effective at preventing or even reversing these treatment toxicities. However, all interventions to date have been of rehabilitative intent being implemented after a minimum of 3 months since initiation of androgen deprivation, by which time considerable physical and psychological health problems have manifested. The pressing question is whether it is more efficacious to commence exercise therapy at the same time as initiating androgen deprivation, so treatment induced adverse effects can be immediately attenuated or indeed prevented. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Chile | 1 | <1% |
Canada | 1 | <1% |
Unknown | 163 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 26 | 16% |
Student > Ph. D. Student | 20 | 12% |
Researcher | 18 | 11% |
Student > Bachelor | 13 | 8% |
Student > Postgraduate | 11 | 7% |
Other | 26 | 16% |
Unknown | 51 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 43 | 26% |
Sports and Recreations | 22 | 13% |
Nursing and Health Professions | 11 | 7% |
Psychology | 11 | 7% |
Agricultural and Biological Sciences | 5 | 3% |
Other | 21 | 13% |
Unknown | 52 | 32% |