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Sida tuberculata (Malvaceae): a study based on development of extractive system and in silico and in vitro properties

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2016
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Title
Sida tuberculata (Malvaceae): a study based on development of extractive system and in silico and in vitro properties
Published in
Brazilian Journal of Medical and Biological Research, January 2016
DOI 10.1590/1414-431x20165282
Pubmed ID
Authors

H.S. da Rosa, A.C.F. Salgueiro, A.Z.C. Colpo, F.R. Paula, A.S.L. Mendez, V. Folmer

Abstract

Sida tuberculata (Malvaceae) is a medicinal plant traditionally used in Brazil as an antimicrobial and anti-inflammatory agent. Here, we aimed to investigate the different extractive techniques on phytochemical parameters, as well as to evaluate the toxicity and antioxidant capacity of S. tuberculata extracts using in silico and in vitro models. Therefore, in order to determine the dry residue content and the main compound 20-hydroxyecdysone (20E) concentration, extracts from leaves and roots were prepared testing ethanol and water in different proportions. Extracts were then assessed by Artemia salina lethality test, and toxicity prediction of 20E was estimated. Antioxidant activity was performed by DPPH and ABTS radical scavenger assays, ferric reducing power assay, nitrogen derivative scavenger, deoxyribose degradation, and TBARS assays. HPLC evaluation detected 20E as main compound in leaves and roots. Percolation method showed the highest concentrations of 20E (0.134 and 0.096 mg/mL of extract for leaves and roots, respectively). All crude extracts presented low toxic potential on A. salina (LD50 >1000 µg/mL). The computational evaluation of 20E showed a low toxicity prediction. For in vitro antioxidant tests, hydroethanolic extracts of leaves were most effective compared to roots. In addition, hydroethanolic extracts presented a higher IC50 antioxidant than aqueous extracts. TBARS formation was prevented by leaves hydroethanolic extract from 0.015 and 0.03 mg/mL and for roots from 0.03 and 0.3 mg/mL on egg yolk and rat tissue, respectively (P<0.05). These findings suggest that S. tuberculata extracts are a considerable source of ecdysteroids and possesses a significant antioxidant property with low toxic potential.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 38%
Student > Doctoral Student 2 15%
Student > Ph. D. Student 1 8%
Student > Master 1 8%
Researcher 1 8%
Other 1 8%
Unknown 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 31%
Pharmacology, Toxicology and Pharmaceutical Science 2 15%
Nursing and Health Professions 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Immunology and Microbiology 1 8%
Other 1 8%
Unknown 3 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#1,018
of 1,254 outputs
Outputs of similar age
#341,819
of 399,677 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#47
of 59 outputs
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So far Altmetric has tracked 1,254 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.