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EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE

Overview of attention for article published in Revista do Instituto de Medicina Tropical de São Paulo, January 2016
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Title
EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE
Published in
Revista do Instituto de Medicina Tropical de São Paulo, January 2016
DOI 10.1590/s1678-9946201658055
Pubmed ID
Authors

Íria Márcia PEREIRA, Sarah Buzaim LIMA, Aline de Araújo FREITAS, Marina Clare VINAUD, Ruy de Souza LINO JUNIOR

Abstract

Human cysticercosis is one of the most severe parasitic infections affecting tissues. Experimental models are needed to understand the host-parasite dynamics involved throughout the course of the infection. The subcutaneous experimental model is the closest to what is observed in human cysticercosis that does not affect the central nervous system. The aim of this study was to evaluate macroscopically and microscopically the experimental subcutaneous cysticercosis caused by Taenia crassiceps cysticerci in BALB/c and C57BL/6 mice. Animals were inoculated in the dorsal subcutaneous region and macroscopic and microscopic aspects of the inflammatory process in the host-parasite interface were evaluated until 90 days after the inoculation (DAI). All the infected animals presented vesicles containing cysticerci in the inoculation site, which was translucent at 7 DAI and then remained opaque throughout the experimental days. The microscopic analysis showed granulation tissue in BALB/c mice since the acute phase of infection evolving to chronicity without cure, presenting 80% of larval stage cysticerci at 90 DAI. While C57BL/6 mice presented 67% of final stage cysticerci at 90 DAI, the parasites were surrounded by neutrophils evolving to the infection control. It is possible to conclude that the genetic features of susceptibility (BALB/c) or resistance (C57BL/6) were confirmed in an experimental subcutaneous model of cysticercosis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 36%
Researcher 5 23%
Student > Doctoral Student 3 14%
Student > Ph. D. Student 1 5%
Student > Master 1 5%
Other 2 9%
Unknown 2 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 18%
Medicine and Dentistry 4 18%
Biochemistry, Genetics and Molecular Biology 3 14%
Nursing and Health Professions 2 9%
Arts and Humanities 2 9%
Other 4 18%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2016.
All research outputs
#11,171,783
of 12,556,257 outputs
Outputs from Revista do Instituto de Medicina Tropical de São Paulo
#251
of 251 outputs
Outputs of similar age
#214,411
of 256,707 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de São Paulo
#1
of 1 outputs
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So far Altmetric has tracked 251 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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