↓ Skip to main content

Range of pathologies diagnosed using a minimally invasive capsule sponge to evaluate patients with reflux symptoms

Overview of attention for article published in Histopathology, October 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
11 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
15 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Range of pathologies diagnosed using a minimally invasive capsule sponge to evaluate patients with reflux symptoms
Published in
Histopathology, October 2016
DOI 10.1111/his.13039
Pubmed ID
Authors

Anna L Paterson, Pierre Lao-Sirieix, Maria O'Donovan, Irene Debiram-Beecham, Massimiliano di Pietro, Ahmad Miremadi, Stephen E Attwood, Fiona M Walter, Peter D Sasieni, Rebecca C Fitzgerald

Abstract

Reflux symptoms are highly prevalent and non-specific hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non-endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms. Two complementary cohorts were recruited: 1) Patients with reflux symptoms and no prior endoscopy (n=409); 2) Patients with reflux symptoms referred for endoscopy (n=411). All patients were investigated using the Cytosponge and endoscopy. Significant epithelial inflammation was present in 130 (16%) Cytosponge samples of which 32 had ulcer slough. Candida and significant inflammation was detected in a further 22 (2.3%) cases; epithelial infiltration with >15 eosinophils/hpf reflecting possible eosinophilic oesophagitis (EOE) in five (0.6%); and viral inclusions suggestive of herpes oesophagitis in one (0.1%). No significant pathology was detected in the majority, 662 (81%), of Cytosponge samples. Cytosponge and endoscopy findings were in agreement in 574 (70%) cases, in most discordant cases, 165 (67%), one investigation showed mild inflammation whilst the other was negative; with an additional 22 (8.9%) differing on the inflammation extent. Eighteen cases with severe inflammation, six with candida and two with EOE were detected only at endoscopy; whilst 18 with candida and significant inflammation, 13 with ulcer slough, one probable EOE, and one viral oesophagitis were identified on the Cytosponge only. The Cytosponge detects a range of benign oesophageal pathologies, and therefore has potential clinical utility in the triaging of patients with troublesome reflux symptoms. This warrants further investigation. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 33%
Researcher 4 27%
Professor 3 20%
Student > Ph. D. Student 1 7%
Student > Doctoral Student 1 7%
Other 1 7%
Readers by discipline Count As %
Medicine and Dentistry 12 80%
Unspecified 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2016.
All research outputs
#1,809,741
of 12,350,637 outputs
Outputs from Histopathology
#133
of 2,150 outputs
Outputs of similar age
#51,813
of 266,497 outputs
Outputs of similar age from Histopathology
#5
of 94 outputs
Altmetric has tracked 12,350,637 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,150 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.