Title |
68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors
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Published in |
EJNMMI Research, September 2012
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DOI | 10.1186/2191-219x-2-52 |
Pubmed ID | |
Authors |
Xiang Li, Samuel Samnick, Constantin Lapa, Ina Israel, Andreas K Buck, Michael C Kreissl, Wolfgang Bauer |
Abstract |
Ga-[1,4,7,10-tetraazacyclododecane-N,N',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophages, which play a major role in inflammatory processes in the walls of coronary arteries and large vessels. Therefore, imaging SSTR expression has the potential to visualize vulnerable plaques. We assessed 68Ga-DOTATATE accumulation in large vessels in comparison to 18F-2-fluorodeoxyglucose (FDG) uptake, calcified plaques (CPs), and cardiovascular risk factors. |
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