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Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

Overview of attention for article published in Journal of Clinical Investigation, January 2012
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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4 tweeters

Citations

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125 Dimensions

Readers on

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126 Mendeley
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Title
Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
Published in
Journal of Clinical Investigation, January 2012
DOI 10.1172/jci42497
Pubmed ID
Authors

Benjamin J. Lamont, Yazhou Li, Edwin Kwan, Theodore J. Brown, Herbert Gaisano, Daniel J. Drucker

Abstract

Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet β cells. GLP-1 also modulates gastric emptying and engages neural circuits in the portal region and CNS that contribute to GLP-1 receptor-dependent (GLP-1R-dependent) regulation of glucose homeostasis. To elucidate the importance of pancreatic GLP-1R signaling for glucose homeostasis, we generated transgenic mice that expressed the human GLP-1R in islets and pancreatic ductal cells (Pdx1-hGLP1R:Glp1r-/- mice). Transgene expression restored GLP-1R-dependent stimulation of cAMP and Akt phosphorylation in isolated islets, conferred GLP-1R-dependent stimulation of β cell proliferation, and was sufficient for restoration of GLP-1-stimulated insulin secretion in perifused islets. Systemic GLP-1R activation with the GLP-1R agonist exendin-4 had no effect on food intake, hindbrain c-fos expression, or gastric emptying but improved glucose tolerance and stimulated insulin secretion in Pdx1-hGLP1R:Glp1r-/- mice. i.c.v. GLP-1R blockade with the antagonist exendin(9-39) impaired glucose tolerance in WT mice but had no effect in Pdx1-hGLP1R:Glp1r-/- mice. Nevertheless, transgenic expression of the pancreatic GLP-1R was sufficient to normalize both oral and i.p. glucose tolerance in Glp1r-/- mice. These findings illustrate that low levels of endogenous GLP-1 secreted from gut endocrine cells are capable of augmenting glucoregulatory activity via pancreatic GLP-1Rs independent of communication with neural pathways.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 2%
Australia 1 <1%
Italy 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Switzerland 1 <1%
Unknown 118 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 36 29%
Student > Ph. D. Student 29 23%
Student > Master 13 10%
Student > Postgraduate 10 8%
Student > Doctoral Student 8 6%
Other 24 19%
Unknown 6 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 32%
Medicine and Dentistry 35 28%
Biochemistry, Genetics and Molecular Biology 22 17%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Social Sciences 2 2%
Other 6 5%
Unknown 14 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2018.
All research outputs
#7,084,357
of 12,552,783 outputs
Outputs from Journal of Clinical Investigation
#11,708
of 13,164 outputs
Outputs of similar age
#61,271
of 129,049 outputs
Outputs of similar age from Journal of Clinical Investigation
#97
of 123 outputs
Altmetric has tracked 12,552,783 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,164 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 129,049 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.