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Pathogenesis of the C3 glomerulopathies and reclassification of MPGN

Overview of attention for article published in Nature Reviews Nephrology, October 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

twitter
6 tweeters
patent
2 patents

Citations

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120 Dimensions

Readers on

mendeley
148 Mendeley
citeulike
1 CiteULike
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Title
Pathogenesis of the C3 glomerulopathies and reclassification of MPGN
Published in
Nature Reviews Nephrology, October 2012
DOI 10.1038/nrneph.2012.213
Pubmed ID
Authors

Andrew S. Bomback, Gerald B. Appel

Abstract

Until recently, membranoproliferative glomerulonephritis (MPGN) was clinically classified as either primary, idiopathic MPGN or as secondary MPGN when an underlying aetiology was identifiable. Primary MPGN was further classified into three types--type I, type II, and type III--based principally on the ultrastructural appearance and location of electron-dense deposits. Both the clinical and histopathologic schemes presented problems, however, as neither was based on disease pathogenesis. An improved understanding of the role of complement in the pathogenesis of MPGN has led to a proposed reclassification into immunoglobulin-mediated disease (driven by the classical complement pathway) and non-immunoglobulin-mediated disease (driven by the alternative complement pathway). This reclassification has led to improved diagnostic clinical algorithms and the emergence of a new grouping of diseases known as the C3 glomerulopathies, best represented by dense deposit disease and C3 glomerulonephritis. In this Review, we re-examine the previous and current classification schemes of MPGN, focusing on the role of complement. We survey current data about the pathogenesis of the C3 glomerulopathies, including familial studies and patient cohorts from the USA and Europe. In addition, we discuss the diagnosis, treatment, and prognosis of the C3 glomerulopathies.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 1%
Malaysia 1 <1%
Bosnia and Herzegovina 1 <1%
Portugal 1 <1%
Unknown 143 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 15%
Other 21 14%
Student > Postgraduate 17 11%
Student > Master 16 11%
Student > Bachelor 13 9%
Other 38 26%
Unknown 21 14%
Readers by discipline Count As %
Medicine and Dentistry 97 66%
Biochemistry, Genetics and Molecular Biology 9 6%
Agricultural and Biological Sciences 8 5%
Immunology and Microbiology 5 3%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 1 <1%
Unknown 24 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2022.
All research outputs
#3,150,815
of 22,100,435 outputs
Outputs from Nature Reviews Nephrology
#702
of 1,714 outputs
Outputs of similar age
#20,979
of 154,485 outputs
Outputs of similar age from Nature Reviews Nephrology
#6
of 35 outputs
Altmetric has tracked 22,100,435 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,485 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.