Title |
Staphylococcal peptidoglycans induce arthritis
|
---|---|
Published in |
Arthritis Research & Therapy, September 2001
|
DOI | 10.1186/ar330 |
Pubmed ID | |
Authors |
Zai-Qing Liu, Guo-Min Deng, Simon Foster, Andrej Tarkowski |
Abstract |
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 26% |
Student > Master | 6 | 22% |
Researcher | 5 | 19% |
Student > Postgraduate | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 2 | 7% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 33% |
Agricultural and Biological Sciences | 7 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Immunology and Microbiology | 3 | 11% |
Environmental Science | 1 | 4% |
Other | 1 | 4% |
Unknown | 3 | 11% |