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Staphylococcal peptidoglycans induce arthritis

Overview of attention for article published in Arthritis Research & Therapy, September 2001
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1 Redditor

Citations

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76 Dimensions

Readers on

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27 Mendeley
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Title
Staphylococcal peptidoglycans induce arthritis
Published in
Arthritis Research & Therapy, September 2001
DOI 10.1186/ar330
Pubmed ID
Authors

Zai-Qing Liu, Guo-Min Deng, Simon Foster, Andrej Tarkowski

Abstract

Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Student > Master 6 22%
Researcher 5 19%
Student > Postgraduate 2 7%
Professor > Associate Professor 2 7%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 9 33%
Agricultural and Biological Sciences 7 26%
Biochemistry, Genetics and Molecular Biology 3 11%
Immunology and Microbiology 3 11%
Environmental Science 1 4%
Other 1 4%
Unknown 3 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2016.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#3,132
of 3,380 outputs
Outputs of similar age
#42,204
of 43,198 outputs
Outputs of similar age from Arthritis Research & Therapy
#7
of 7 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 43,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.