Title |
Diarrheal disease and enteric infections in LMIC communities: how big is the problem?
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Published in |
Tropical Diseases, Travel Medicine and Vaccines, July 2016
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DOI | 10.1186/s40794-016-0028-7 |
Pubmed ID | |
Authors |
Benjamin J. J. McCormick, Dennis R. Lang |
Abstract |
Studies of enteric diseases have historically focused on observations of clinical diarrhea as a cause of mortality and morbidity. Emerging evidence suggests that diarrhea dramatically underestimates both exposure to enteropathogens and the long-term consequences arising from infection. High burden of pathogens in the gut, even in the absence of diarrhea, is common in infants in low and middle income countries. Continual challenge by pathogens, in conjunction with an inadequate diet stimulates an inflammatory disease that alters the structure of the gut, metabolic and immunological pathways and changes the microbiome. Both diarrhea and enteropathogen infection have been associated with reduced growth, reduced cognitive development, and reduced vaccine efficacy suggesting that the burden of diarrheal disease is dramatically underestimated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 8% |
Bangladesh | 1 | 8% |
Ireland | 1 | 8% |
Uganda | 1 | 8% |
United Kingdom | 1 | 8% |
Switzerland | 1 | 8% |
United States | 1 | 8% |
Unknown | 5 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 67% |
Practitioners (doctors, other healthcare professionals) | 3 | 25% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 111 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 17% |
Researcher | 15 | 14% |
Student > Bachelor | 14 | 13% |
Student > Master | 14 | 13% |
Other | 7 | 6% |
Other | 16 | 14% |
Unknown | 26 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 17% |
Nursing and Health Professions | 14 | 13% |
Agricultural and Biological Sciences | 9 | 8% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Immunology and Microbiology | 8 | 7% |
Other | 25 | 23% |
Unknown | 28 | 25% |