Title |
Detection for gene-gene co-association via kernel canonical correlation analysis
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Published in |
BMC Genomic Data, October 2012
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DOI | 10.1186/1471-2156-13-83 |
Pubmed ID | |
Authors |
Zhongshang Yuan, Qingsong Gao, Yungang He, Xiaoshuai Zhang, Fangyu Li, Jinghua Zhao, Fuzhong Xue |
Abstract |
Currently, most methods for detecting gene-gene interaction (GGI) in genomewide association studies (GWASs) are limited in their use of single nucleotide polymorphism (SNP) as the unit of association. One way to address this drawback is to consider higher level units such as genes or regions in the analysis. Earlier we proposed a statistic based on canonical correlations (CCU) as a gene-based method for detecting gene-gene co-association. However, it can only capture linear relationship and not nonlinear correlation between genes. We therefore proposed a counterpart (KCCU) based on kernel canonical correlation analysis (KCCA). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 24% |
Professor > Associate Professor | 4 | 16% |
Student > Master | 3 | 12% |
Researcher | 3 | 12% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 28% |
Readers by discipline | Count | As % |
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Computer Science | 6 | 24% |
Agricultural and Biological Sciences | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Engineering | 2 | 8% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |