Title |
Effect of sample stratification on dairy GWAS results
|
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Published in |
BMC Genomics, October 2012
|
DOI | 10.1186/1471-2164-13-536 |
Pubmed ID | |
Authors |
Li Ma, George R Wiggans, Shengwen Wang, Tad S Sonstegard, Jing Yang, Brian A Crooker, John B Cole, Curtis P Van Tassell, Thomas J Lawlor, Yang Da |
Abstract |
Artificial insemination and genetic selection are major factors contributing to population stratification in dairy cattle. In this study, we analyzed the effect of sample stratification and the effect of stratification correction on results of a dairy genome-wide association study (GWAS). Three methods for stratification correction were used: the efficient mixed-model association expedited (EMMAX) method accounting for correlation among all individuals, a generalized least squares (GLS) method based on half-sib intraclass correlation, and a principal component analysis (PCA) approach. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Colombia | 1 | 2% |
Canada | 1 | 2% |
Unknown | 56 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 25% |
Student > Ph. D. Student | 10 | 17% |
Student > Master | 8 | 13% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Other | 10 | 17% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 58% |
Veterinary Science and Veterinary Medicine | 4 | 7% |
Computer Science | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 12 | 20% |