Title |
Prognostic significance of c-KIT in vulvar cancer: bringing this molecular marker from bench to bedside
|
---|---|
Published in |
Journal of Translational Medicine, July 2012
|
DOI | 10.1186/1479-5876-10-150 |
Pubmed ID | |
Authors |
Beatriz de Melo Maia, André Mourão Lavorato-Rocha, Iara Sant’Ana Rodrigues, Glauco Baiocchi, Flávia Munhoz Cestari, Monica Maria Stiepcich, Ludmila Thomé Domingues Chinen, Kátia C Carvalho, Fernando Augusto Soares, Rafael Malagoli Rocha |
Abstract |
Vulvar carcinomas are rare tumors, and there is limited data regarding molecular alterations. To our knowledge there are no published studies on c-KIT and squamous cell carcinomas of the vulva (VSCC). Although there are a significant number of other tumor types which express c-KIT, there remains controversy as to its relationship to patient outcome. Thus, we wished to investigate such controversial findings to determine the prognostic importance of c-KIT by evaluating its protein and mRNA expression in VSCCs, correlating these findings with clinicopathological features and Human Papillomavirus (HPV) infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 33 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 20% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Bachelor | 3 | 9% |
Professor | 3 | 9% |
Other | 7 | 20% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 29% |
Agricultural and Biological Sciences | 6 | 17% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Nursing and Health Professions | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 4 | 11% |
Unknown | 6 | 17% |