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Multipotent Stem Cells of the Hair Follicle

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Cover of 'Multipotent Stem Cells of the Hair Follicle'

Table of Contents

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    Book Overview
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    Chapter 1 Multipotent Stem Cells of the Hair Follicle
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    Chapter 2 Nestin-Based Reporter Transgenic Mouse Lines.
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    Chapter 3 Discovery of HAP Stem Cells.
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    Chapter 4 Multipotent Stem Cells of the Hair Follicle
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    Chapter 5 Construction of Tissue-Engineered Nerve Conduits Seeded with Neurons Derived from Hair-Follicle Neural Crest Stem Cells.
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    Chapter 6 Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Promote Whisker Sensory-Nerve Growth in Long-Term 3D-Gelfoam® Histoculture.
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    Chapter 7 Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles.
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    Chapter 8 Isolation of Mouse Hair Follicle Bulge Stem Cells and Their Functional Analysis in a Reconstitution Assay.
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    Chapter 9 Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ.
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    Chapter 10 Hair Induction by Cultured Mesenchymal Cells Using Sphere Formation.
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    Chapter 11 Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing.
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    Chapter 12 Culture of Dermal Papilla Cells from Ovine Wool Follicles: An In Vitro Model for Papilla Size Determination.
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    Chapter 13 Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.
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    Chapter 14 Protocols for Ectopic Hair Growth from Transplanted Whisker Follicles on the Spinal Cord of Mice.
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    Chapter 15 Protocols for Gelfoam(®) Histoculture of Hair-Shaft-Producing Mouse Whisker Follicles Containing Nestin-GFP-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Long Time Periods.
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    Chapter 16 Multipotent Stem Cells of the Hair Follicle
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    Chapter 17 Highly Efficient Neural Differentiation of CD34-Positive Hair-Follicle-Associated Pluripotent Stem Cells Induced by Retinoic Acid and Serum-Free Medium.
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    Chapter 18 Multipotent Stem Cells of the Hair Follicle
Attention for Chapter 3: Discovery of HAP Stem Cells.
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Citations

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Chapter title
Discovery of HAP Stem Cells.
Chapter number 3
Book title
Multipotent Stem Cells of the Hair Follicle
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3786-8_3
Pubmed ID
Book ISBNs
978-1-4939-3784-4, 978-1-4939-3786-8
Authors

Lingna Li, Robert M. Hoffman

Editors

Robert M Hoffman

Abstract

Cells expressing the stem cell marker, nestin, were selectively labeled in transgenic mice by placing green fluorescent protein (GFP) under the control of the nestin promoter in transgenic mice. In these transgenic mice, neural and other stem cells brightly expressed GFP. The mice were termed nestin-driven GFP (ND-GFP) mice. During early anagen or growth phase of the hair follicle, ND-GFP appeared in the permanent upper hair follicle immediately below the sebaceous glands in the follicle bulge. The relatively small, oval-shaped, nestin-expressing cells in the bulge area surrounded the hair shaft and were interconnected by short dendrites. The location of the nestin-expressing cells in the hair follicle varied with the hair cycle. During telogen or resting phase and in early anagen, the GFP-positive cells are mainly in the bulge area. However, in mid- and late-anagen, the GFP-expressing cells were located in the upper outer-root sheath as well as in the bulge area. The expression of the unique protein, nestin, in both neural stem cells and hair follicle stem cells, which suggested their relationship. The ND-GFP hair follicle stem cells were later termed hair-follicle-associated pluripotent (HAP) stem cells.