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68Ga-Prostate-specific membrane antigen (psma) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis.

Overview of attention for article published in International braz j urol : official journal of the Brazilian Society of Urology, February 2021
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Title
68Ga-Prostate-specific membrane antigen (psma) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis.
Published in
International braz j urol : official journal of the Brazilian Society of Urology, February 2021
DOI 10.1590/s1677-5538.ibju.2019.0817
Pubmed ID
Authors

Matushita, Cristina S, da Silva, Ana M Marques, Schuck, Phelipi N, Bardisserotto, Matteo, Piant, Diego B, Pereira, Jonatas L, Cerci, Juliano J, Coura-Filho, George B, Esteves, Fabio P, Amorim, Barbara J, Gomes, Gustavo V, Brito, Ana Emília T, Bernardo, Wanderley M, Mundstock, Eduardo, Fanti, Stefano, Macedo, Bruna, Roman, Diego H, Tem-Pass, Cinthia Scatolin, Hochhegger, Bruno

Abstract

Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors: 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05. pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions. 68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer.

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 20%
Student > Doctoral Student 2 20%
Other 1 10%
Professor 1 10%
Student > Master 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 6 60%
Arts and Humanities 1 10%
Unknown 3 30%