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68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis

Overview of attention for article published in International Brazilian Journal of Urology, August 2021
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2 tweeters

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45 Mendeley
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Title
68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis
Published in
International Brazilian Journal of Urology, August 2021
DOI 10.1590/s1677-5538.ibju.2019.0817
Pubmed ID
Authors

Cristina S. Matushita, Ana M. Marques da Silva, Phelipi N. Schuck, Matteo Bardisserotto, Diego B. Piant, Jonatas L. Pereira, Juliano J. Cerci, George B. Coura Filho, Fabio P. Esteves, Barbara J. Amorim, Gustavo V. Gomes, Ana Emília T. Brito, Wanderley M. Bernardo, Eduardo Mundstock, Stefano Fanti, Bruna Macedo, Diego H. Roman, Cinthia Scatolin Tem-Pass, Bruno Hochhegger

Abstract

Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors: 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05. pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions. 68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 9%
Other 3 7%
Student > Ph. D. Student 3 7%
Student > Doctoral Student 3 7%
Student > Bachelor 2 4%
Other 8 18%
Unknown 22 49%
Readers by discipline Count As %
Medicine and Dentistry 10 22%
Unspecified 4 9%
Business, Management and Accounting 3 7%
Computer Science 1 2%
Arts and Humanities 1 2%
Other 2 4%
Unknown 24 53%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2021.
All research outputs
#14,836,083
of 22,846,662 outputs
Outputs from International Brazilian Journal of Urology
#309
of 691 outputs
Outputs of similar age
#232,448
of 430,903 outputs
Outputs of similar age from International Brazilian Journal of Urology
#2
of 6 outputs
Altmetric has tracked 22,846,662 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 691 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,903 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.