Title |
Limitations and advances in new treatments and future perspectives of corneal blindness.
|
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Published in |
Arquivos Brasileiros de Oftalmologia, January 2021
|
DOI | 10.5935/0004-2749.20210042 |
Pubmed ID | |
Authors |
Rosalia Antunes-Foschini, Leidiane Adriano, Adriana de Andrade Batista Murashima, Amanda Pires Barbosa, Luis Fernando Nominato, Lara Cristina Dias, Marina Zilio Fantucci, Denny Marcos Garcia, Monica Alves, Eduardo Melani Rocha |
Abstract |
This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and tissue reengineering as potential future strategies to work solely or in combination with corneal surgery to prevent or revert corneal blindness. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 21% |
Student > Bachelor | 2 | 14% |
Student > Master | 2 | 14% |
Student > Doctoral Student | 1 | 7% |
Student > Ph. D. Student | 1 | 7% |
Other | 0 | 0% |
Unknown | 5 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 21% |
Engineering | 2 | 14% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Computer Science | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 43% |