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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, February 2015
|
| DOI | 10.1002/anie.201410810 |
| Pubmed ID | |
| Authors |
Anna Barnard, Kérya Long, Heather L. Martin, Jennifer A. Miles, Thomas A. Edwards, Darren C. Tomlinson, Andrew Macdonald, Andrew J. Wilson |
| Abstract |
Inhibition of protein-protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed "proteomimetics", which can be assembled in a modular manner to reproduce the vectoral presentation of key side chains found on a helical motif from one partner within the PPI. In this work, it is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent helix mimetics which reproduce their biophysical binding selectivity in a cellular context can be identified. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 40% |
| United States | 2 | 20% |
| Germany | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 6 | 60% |
| Members of the public | 4 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| India | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 97 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 24% |
| Researcher | 21 | 21% |
| Student > Master | 16 | 16% |
| Student > Bachelor | 12 | 12% |
| Student > Doctoral Student | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 65 | 64% |
| Agricultural and Biological Sciences | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Physics and Astronomy | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Other | 3 | 3% |
| Unknown | 13 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2015.
All research outputs
#6,929,388
of 25,373,627 outputs
Outputs from Angewandte Chemie. International Edition
#20,735
of 49,982 outputs
Outputs of similar age
#86,885
of 360,574 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#297
of 692 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 49,982 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,574 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 692 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.