Title |
Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes
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Published in |
Current Opinion in Virology, August 2018
|
DOI | 10.1016/j.coviro.2018.08.001 |
Pubmed ID | |
Authors |
Alexander Borodavka, Ulrich Desselberger, John T Patton |
Abstract |
Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA-protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific inter-molecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 33% |
France | 3 | 25% |
South Africa | 1 | 8% |
Spain | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 2 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 75% |
Scientists | 3 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 22% |
Researcher | 14 | 19% |
Student > Doctoral Student | 7 | 10% |
Student > Master | 7 | 10% |
Student > Bachelor | 6 | 8% |
Other | 11 | 15% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 42% |
Agricultural and Biological Sciences | 13 | 18% |
Immunology and Microbiology | 3 | 4% |
Chemistry | 2 | 3% |
Medicine and Dentistry | 2 | 3% |
Other | 6 | 8% |
Unknown | 16 | 22% |