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Eficacia y seguridad de distintas cepas de BCG en el tratamiento del tumor vesical en práctica clínica habitual

Overview of attention for article published in Actas Urologicas Espanolas - English Edition, December 2017
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Title
Eficacia y seguridad de distintas cepas de BCG en el tratamiento del tumor vesical en práctica clínica habitual
Published in
Actas Urologicas Espanolas - English Edition, December 2017
DOI 10.1016/j.acuro.2017.10.003
Pubmed ID
Authors

M. Unda-Urzaiz, J.M. Cozar-Olmos, B. Miñana-Lopez, J. Camarero-Jimenez, X. Brugarolas-Rossello, C. Zubiaur-Libano, M.J. Ribal-Caparros, A.J. Suarez-Charneco, V. Rodriguez-Tesedo, V. Chantada-Abal, C. Ruiz-de-Leon, C. Carrillo-George, J. Carballido-Rodriguez, F. Villacampa-Auba, en del Grupo Español del de Cepas de representación Registro BCG

Abstract

The natural progression of bladder tumours (nonmuscle-invasive bladder cancer [NMIBC]) is recurrence with a high rate of progression. Bacille Calmette-Guérin (BCG) has been shown effective in reducing these rates, but there are few comparative studies between strains. An observational, prospective and multicentre registry studied 433 patients with a 12-month follow-up visit from 961 registered patients, assessing disease-free survival (DFS), progression-free survival (PFS) cancer-specific survival (CSS) and adverse effects. We studied the Tice, Russian, Tokyo, Connaught and RIVM strains. The sociodemographic data, NMIBC history, comorbidities, size, number, stage, grade, associated carcinoma in situ and transurethral resection were well balanced. DFS: There were 85 relapses (19.6%). The median DFS time was 20months. When comparing the various strains, we detected no statistically significant differences (log-rank test; P=.93). LPS: There were 33 cases of progression (7.62%). When comparing the various strains, we detected no statistically significant differences (log-rank test; P=.69). CSS: Seven patients died (1.68%). When comparing the various strains, we detected no statistically significant differences (log-rank test; P=.93). In terms of safety, 33.3% of the patients presented some type of adverse effect, mostly lower urinary symptoms (no urinary tract infections) <48h, >48h and haematuria. According to the Common Toxicity Criteria of the European Organisation for Research and Treatment of Cancer, 92.7% of the patients were grade1. There were no statistically significant differences between the strains. In this intermediate analysis, the risk of recurrence, progression, specific death and safety were independent of the BCG strain employed.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 23%
Student > Ph. D. Student 4 15%
Student > Postgraduate 3 12%
Researcher 2 8%
Professor 1 4%
Other 3 12%
Unknown 7 27%
Readers by discipline Count As %
Medicine and Dentistry 8 31%
Biochemistry, Genetics and Molecular Biology 4 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Business, Management and Accounting 1 4%
Nursing and Health Professions 1 4%
Other 1 4%
Unknown 9 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2019.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from Actas Urologicas Espanolas - English Edition
#159
of 315 outputs
Outputs of similar age
#270,219
of 449,137 outputs
Outputs of similar age from Actas Urologicas Espanolas - English Edition
#7
of 11 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 315 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,137 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.