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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain
|
|---|---|
| Published in |
Cell Reports, October 2016
|
| DOI | 10.1016/j.celrep.2016.09.075 |
| Pubmed ID | |
| Authors |
Prabesh Bhattarai, Alvin Kuriakose Thomas, Mehmet Ilyas Cosacak, Christos Papadimitriou, Violeta Mashkaryan, Cynthia Froc, Susanne Reinhardt, Thomas Kurth, Andreas Dahl, Yixin Zhang, Caghan Kizil |
| Abstract |
Human brains are prone to neurodegeneration, given that endogenous neural stem/progenitor cells (NSPCs) fail to support neurogenesis. To investigate the molecular programs potentially mediating neurodegeneration-induced NSPC plasticity in regenerating organisms, we generated an Amyloid-β42 (Aβ42)-dependent neurotoxic model in adult zebrafish brain through cerebroventricular microinjection of cell-penetrating Aβ42 derivatives. Aβ42 deposits in neurons and causes phenotypes reminiscent of amyloid pathophysiology: apoptosis, microglial activation, synaptic degeneration, and learning deficits. Aβ42 also induces NSPC proliferation and enhanced neurogenesis. Interleukin-4 (IL4) is activated primarily in neurons and microglia/macrophages in response to Aβ42 and is sufficient to increase NSPC proliferation and neurogenesis via STAT6 phosphorylation through the IL4 receptor in NSPCs. Our results reveal a crosstalk between neurons and immune cells mediated by IL4/STAT6 signaling, which induces NSPC plasticity in zebrafish brains. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 33% |
| Germany | 7 | 17% |
| Turkey | 5 | 12% |
| Italy | 1 | 2% |
| France | 1 | 2% |
| Unknown | 14 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 71% |
| Scientists | 10 | 24% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 184 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 23% |
| Student > Bachelor | 23 | 13% |
| Researcher | 22 | 12% |
| Student > Master | 18 | 10% |
| Student > Doctoral Student | 13 | 7% |
| Other | 19 | 10% |
| Unknown | 46 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 41 | 22% |
| Agricultural and Biological Sciences | 37 | 20% |
| Biochemistry, Genetics and Molecular Biology | 31 | 17% |
| Medicine and Dentistry | 9 | 5% |
| Immunology and Microbiology | 4 | 2% |
| Other | 17 | 9% |
| Unknown | 45 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 180. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2024.
All research outputs
#222,821
of 25,374,917 outputs
Outputs from Cell Reports
#302
of 12,960 outputs
Outputs of similar age
#4,376
of 332,577 outputs
Outputs of similar age from Cell Reports
#10
of 300 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,960 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,577 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 300 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.