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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural diversity of supercoiled DNA
|
|---|---|
| Published in |
Nature Communications, October 2015
|
| DOI | 10.1038/ncomms9440 |
| Pubmed ID | |
| Authors |
Rossitza N. Irobalieva, Jonathan M. Fogg, Daniel J. Catanese, Thana Sutthibutpong, Muyuan Chen, Anna K. Barker, Steven J. Ludtke, Sarah A. Harris, Michael F. Schmid, Wah Chiu, Lynn Zechiedrich |
| Abstract |
By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unknown. Here we use electron cryo-tomography together with biochemical analyses to investigate structures of individual purified DNA minicircle topoisomers with defined degrees of supercoiling. Our results reveal that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution of three-dimensional conformations. Moreover, we uncover striking differences in how the topoisomers handle torsional stress. As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA. Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA. Our integrated approach reveals the three-dimensional structures of DNA that are essential for its function. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 29% |
| United Kingdom | 3 | 9% |
| Canada | 2 | 6% |
| Germany | 2 | 6% |
| Chile | 1 | 3% |
| Brazil | 1 | 3% |
| Australia | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 13 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 76% |
| Scientists | 7 | 21% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 310 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| India | 1 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| China | 1 | <1% |
| Taiwan | 1 | <1% |
| Greece | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 298 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 94 | 30% |
| Student > Bachelor | 43 | 14% |
| Researcher | 35 | 11% |
| Student > Master | 22 | 7% |
| Student > Doctoral Student | 18 | 6% |
| Other | 39 | 13% |
| Unknown | 59 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 82 | 26% |
| Agricultural and Biological Sciences | 60 | 19% |
| Physics and Astronomy | 26 | 8% |
| Chemistry | 26 | 8% |
| Engineering | 10 | 3% |
| Other | 39 | 13% |
| Unknown | 67 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 379. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#83,554
of 25,765,370 outputs
Outputs from Nature Communications
#1,255
of 58,371 outputs
Outputs of similar age
#1,007
of 292,688 outputs
Outputs of similar age from Nature Communications
#12
of 775 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,371 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 775 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.