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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development
|
|---|---|
| Published in |
Molecular Psychiatry, April 2012
|
| DOI | 10.1038/mp.2012.29 |
| Pubmed ID | |
| Authors |
M Lange, W Norton, M Coolen, M Chaminade, S Merker, F Proft, A Schmitt, P Vernier, K-P Lesch, L Bally-Cuif |
| Abstract |
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, increased impulsivity and emotion dysregulation. Linkage analysis followed by fine-mapping identified variation in the gene coding for Latrophilin 3 (LPHN3), a putative adhesion-G protein-coupled receptor, as a risk factor for ADHD. In order to validate the link between LPHN3 and ADHD, and to understand the function of LPHN3 in the etiology of the disease, we examined its ortholog lphn3.1 during zebrafish development. Loss of lphn3.1 function causes a reduction and misplacement of dopamine-positive neurons in the ventral diencephalon and a hyperactive/impulsive motor phenotype. The behavioral phenotype can be rescued by the ADHD treatment drugs methylphenidate and atomoxetine. Together, our results implicate decreased Lphn3 activity in eliciting ADHD-like behavior, and demonstrate its correlated contribution to the development of the brain dopaminergic circuitry. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| New Zealand | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Greece | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 198 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 33 | 16% |
| Researcher | 32 | 16% |
| Student > Ph. D. Student | 29 | 14% |
| Student > Master | 16 | 8% |
| Other | 11 | 5% |
| Other | 35 | 17% |
| Unknown | 49 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 23% |
| Neuroscience | 33 | 16% |
| Biochemistry, Genetics and Molecular Biology | 26 | 13% |
| Medicine and Dentistry | 11 | 5% |
| Psychology | 9 | 4% |
| Other | 19 | 9% |
| Unknown | 59 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2014.
All research outputs
#3,325,602
of 23,510,717 outputs
Outputs from Molecular Psychiatry
#2,056
of 4,221 outputs
Outputs of similar age
#21,426
of 163,386 outputs
Outputs of similar age from Molecular Psychiatry
#15
of 45 outputs
Altmetric has tracked 23,510,717 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,221 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.