Title |
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis
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Published in |
Molecular Psychiatry, May 2016
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DOI | 10.1038/mp.2016.72 |
Pubmed ID | |
Authors |
T Wise, J Radua, E Via, N Cardoner, O Abe, T M Adams, F Amico, Y Cheng, J H Cole, C de Azevedo Marques Périco, D P Dickstein, T F D Farrow, T Frodl, G Wagner, I H Gotlib, O Gruber, B J Ham, D E Job, M J Kempton, M J Kim, P C M P Koolschijn, G S Malhi, D Mataix-Cols, A M McIntosh, A C Nugent, J T O'Brien, S Pezzoli, M L Phillips, P S Sachdev, G Salvadore, S Selvaraj, A C Stanfield, A J Thomas, M J van Tol, N J A van der Wee, D J Veltman, A H Young, C H Fu, A J Cleare, D Arnone |
Abstract |
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.72. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 40% |
United States | 1 | 10% |
Japan | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 80% |
Scientists | 2 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Australia | 1 | <1% |
Unknown | 434 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 63 | 14% |
Researcher | 53 | 12% |
Student > Bachelor | 37 | 8% |
Student > Doctoral Student | 34 | 8% |
Student > Master | 28 | 6% |
Other | 79 | 18% |
Unknown | 145 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 73 | 17% |
Psychology | 65 | 15% |
Medicine and Dentistry | 61 | 14% |
Agricultural and Biological Sciences | 13 | 3% |
Biochemistry, Genetics and Molecular Biology | 12 | 3% |
Other | 39 | 9% |
Unknown | 176 | 40% |