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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos
|
|---|---|
| Published in |
Scientific Reports, March 2017
|
| DOI | 10.1038/srep43786 |
| Pubmed ID | |
| Authors |
Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix |
| Abstract |
Thyroid hormones are essential for normal brain development in vertebrates. In humans, abnormal maternal thyroid hormone levels during early pregnancy are associated with decreased offspring IQ and modified brain structure. As numerous environmental chemicals disrupt thyroid hormone signalling, we questioned whether exposure to ubiquitous chemicals affects thyroid hormone responses during early neurogenesis. We established a mixture of 15 common chemicals at concentrations reported in human amniotic fluid. An in vivo larval reporter (GFP) assay served to determine integrated thyroid hormone transcriptional responses. Dose-dependent effects of short-term (72 h) exposure to single chemicals and the mixture were found. qPCR on dissected brains showed significant changes in thyroid hormone-related genes including receptors, deiodinases and neural differentiation markers. Further, exposure to mixture also modified neural proliferation as well as neuron and oligodendrocyte size. Finally, exposed tadpoles showed behavioural responses with dose-dependent reductions in mobility. In conclusion, exposure to a mixture of ubiquitous chemicals at concentrations found in human amniotic fluid affect thyroid hormone-dependent transcription, gene expression, brain development and behaviour in early embryogenesis. As thyroid hormone signalling is strongly conserved across vertebrates the results suggest that ubiquitous chemical mixtures could be exerting adverse effects on foetal human brain development. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 14% |
| France | 4 | 14% |
| United Kingdom | 3 | 11% |
| Germany | 1 | 4% |
| Netherlands | 1 | 4% |
| Belgium | 1 | 4% |
| Madagascar | 1 | 4% |
| Comoros | 1 | 4% |
| Canada | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 64% |
| Scientists | 6 | 21% |
| Practitioners (doctors, other healthcare professionals) | 4 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 19% |
| Student > Bachelor | 14 | 16% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Master | 10 | 11% |
| Other | 6 | 7% |
| Other | 11 | 12% |
| Unknown | 21 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Environmental Science | 10 | 11% |
| Medicine and Dentistry | 8 | 9% |
| Neuroscience | 8 | 9% |
| Other | 15 | 17% |
| Unknown | 26 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 84. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2023.
All research outputs
#485,802
of 24,649,404 outputs
Outputs from Scientific Reports
#5,380
of 134,538 outputs
Outputs of similar age
#10,477
of 312,639 outputs
Outputs of similar age from Scientific Reports
#207
of 4,597 outputs
Altmetric has tracked 24,649,404 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 134,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,639 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4,597 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.