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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions
|
|---|---|
| Published in |
Chemical Science, January 2017
|
| DOI | 10.1039/c7sc00388a |
| Pubmed ID | |
| Authors |
George M. Burslem, Hannah F. Kyle, Adam Nelson, Thomas A. Edwards, Andrew J. Wilson |
| Abstract |
The modulation of protein-protein interactions (PPIs) represents a major challenge in modern chemical biology. Current approaches (e.g. high-throughput screening, computer aided ligand design) are recognised as having limitations in terms of identification of hit matter. Considerable success has been achieved in terms of developing new approaches to PPI modulator discovery using the p53/hDM2 and Bcl-2 family of PPIs. However these important targets in oncology might be considered as "low-hanging-fruit". Hypoxia inducible factor (HIF) is an emerging, but not yet fully validated target for cancer chemotherapy. Its role is to regulate the hypoxic response and it does so through a plethora of protein-protein interactions of varying topology, topography and complexity: its modulation represents an attractive approach to prevent development of new vasculature by hypoxic tumours. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 27% |
| United States | 3 | 27% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 6 | 55% |
| Members of the public | 4 | 36% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Unknown | 102 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 24% |
| Student > Master | 18 | 17% |
| Researcher | 14 | 13% |
| Student > Bachelor | 10 | 10% |
| Professor > Associate Professor | 4 | 4% |
| Other | 11 | 11% |
| Unknown | 22 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 30 | 29% |
| Biochemistry, Genetics and Molecular Biology | 19 | 18% |
| Agricultural and Biological Sciences | 10 | 10% |
| Medicine and Dentistry | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 13 | 13% |
| Unknown | 25 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2022.
All research outputs
#2,895,195
of 23,563,389 outputs
Outputs from Chemical Science
#1,535
of 8,177 outputs
Outputs of similar age
#59,173
of 423,888 outputs
Outputs of similar age from Chemical Science
#89
of 612 outputs
Altmetric has tracked 23,563,389 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,177 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,888 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 612 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.