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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2)
|
|---|---|
| Published in |
Microbiology, September 2017
|
| DOI | 10.1099/mic.0.000524 |
| Pubmed ID | |
| Authors |
Nicolle F. Som, Daniel Heine, Neil Holmes, Felicity Knowles, Govind Chandra, Ryan F. Seipke, Paul A. Hoskisson, Barrie Wilkinson, Matthew I. Hutchings |
| Abstract |
MtrAB is a highly conserved two-component system implicated in the regulation of cell division in the Actinobacteria. It coordinates DNA replication with cell division in the unicellular Mycobacterium tuberculosis and links antibiotic production to sporulation in the filamentous Streptomyces venezuelae. Chloramphenicol biosynthesis is directly regulated by MtrA in S. venezuelae and deletion of mtrB constitutively activates MtrA and results in constitutive over-production of chloramphenicol. Here we report that in Streptomyces coelicolor, MtrA binds to sites upstream of developmental genes and the genes encoding ActII-1, ActII-4 and RedZ, which are cluster-situated regulators of the antibiotics actinorhodin (Act) and undecylprodigiosin (Red). Consistent with this, deletion of mtrB switches on the production of Act, Red and streptorubin B, a product of the Red pathway. Thus, we propose that MtrA is a key regulator that links antibiotic production to development and can be used to upregulate antibiotic production in distantly related streptomycetes. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 17 | 50% |
| France | 2 | 6% |
| Germany | 1 | 3% |
| Unknown | 14 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 65% |
| Scientists | 11 | 32% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Student > Bachelor | 12 | 16% |
| Student > Master | 11 | 15% |
| Researcher | 3 | 4% |
| Professor > Associate Professor | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 26 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 24% |
| Biochemistry, Genetics and Molecular Biology | 15 | 20% |
| Immunology and Microbiology | 6 | 8% |
| Chemistry | 2 | 3% |
| Environmental Science | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 30 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2018.
All research outputs
#1,753,663
of 25,382,440 outputs
Outputs from Microbiology
#116
of 5,709 outputs
Outputs of similar age
#33,573
of 323,665 outputs
Outputs of similar age from Microbiology
#2
of 40 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,709 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,665 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.