Title |
Changes in arginine are inversely associated with type 2 diabetes: A case‐cohort study in the PREDIMED trial
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Published in |
Diabetes, Obesity & Metabolism, October 2018
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DOI | 10.1111/dom.13514 |
Pubmed ID | |
Authors |
Edward Yu, Miguel Ruiz‐Canela, Cristina Razquin, Marta Guasch‐Ferré, Estefania Toledo, Dong D. Wang, Christopher Papandreou, Courtney Dennis, Clary Clish, Liming Liang, Monica Bullo, Dolores Corella, Montserrat Fitó, Mario Gutiérrez‐Bedmar, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra‐Majem, Jose V. Sorlí, Jordi Salas‐Salvadó, Frank B. Hu, Miguel A. Martínez‐González |
Abstract |
The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design nested within the PREDIMED trial to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. 1-year changes in arginine (Adjusted HR per SD = 0.68, 95% CI = 0.49, 0.95; Q4 vs. Q1 = 0.46, 95% CI = 0.21, 1.04, p-trend = 0.02) and arginine/ADMA ratio (Adjusted HR per SD = 0.73, 95% CI = 0.51, 1.04; Q4 vs. Q1 = 0.52, 95% CI = 0.22, 1.25, p-trend = 0.04) were associated with lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine+citrulline) were associated with concurrent 1-year changes in HOMA-IR. Individuals in the low fat diet group experienced higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean diet groups (p-interaction = 0.02). Arginine bioavailability is important in T2D pathophysiology. This article is protected by copyright. All rights reserved. |
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Geographical breakdown
Country | Count | As % |
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Spain | 8 | 57% |
United States | 2 | 14% |
France | 1 | 7% |
Comoros | 1 | 7% |
Unknown | 2 | 14% |
Demographic breakdown
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Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 17% |
Researcher | 9 | 13% |
Student > Master | 7 | 10% |
Student > Ph. D. Student | 5 | 7% |
Professor | 5 | 7% |
Other | 16 | 22% |
Unknown | 18 | 25% |
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Nursing and Health Professions | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Agricultural and Biological Sciences | 3 | 4% |
Engineering | 2 | 3% |
Other | 6 | 8% |
Unknown | 27 | 38% |