Title |
Nilotinib as Coadjuvant Treatment with Doxorubicin in Patients with Sarcomas: A Phase I Trial of the Spanish Group for Research on Sarcoma
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Published in |
Clinical Cancer Research, November 2018
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DOI | 10.1158/1078-0432.ccr-18-0851 |
Pubmed ID | |
Authors |
Regina Alemany, David S. Moura, Andres Redondo, Javier Martinez-Trufero, Silvia Calabuig, Carlos Saus, Antonia Obrador-Hevia, Rafael Ramos, Victor H. Villar, Claudia Valverde, Maria Angeles Vaz, Javier Medina, Irene Felipe-Abrio, Nadia Hindi, Miguel Taron, Javier Martin-Broto |
Abstract |
Nilotinib plus doxorubicin showed to be synergistic regarding apoptosis in several sarcoma cell lines. A phase I/II trial was thus designed to explore the feasibility of nilotinib as co-adjuvant of doxorubicin by inhibiting MRP-1/ P-gp efflux activity. The phase I part of the study is presented here. Nilotinib 400 mg/12 h was administered in fixed dose from day 1 to 6, and doxorubicin on day 5 of each cycle. Three dose-escalation levels for doxorubicin at 60 mg/m2, 65 mg/m2 and 75 mg/m2 were planned. Cycles were repeated every 3 weeks for a total of 4 cycles. Eligible subtypes were retroperitoneal liposarcoma (LPS), leiomyosarcoma (LMS) and unresectable/ metastatic high-grade chondrosarcoma (CHO). Thirteen patients were enrolled: 7 CHO, 4 LPS and 2 LMS. In 46 cycles administered, the most relevant grade 3/4 adverse effects per patient were: neutropenia 54%, febrile neutropenia 15%, and asthenia 8%. No cardiac toxicity was observed. Only one dose-limiting toxicity (febrile neutropenia) was reported in the third dose-level. As regards efficacy, there were 1 partial response (1 LPS), 9 SD (5 CHO, 2 LPS, 1 LMS) and 3 progressive diseases (2 CHO and 1 LMS). ABCB1 and ABCC1 RNA expression levels decreased by 58.47-fold and 1.47-fold respectively on day 5 of the cycle. Combination of MRP-1/P-gp inhibitor, nilotinib, as co-adjuvant with doxorubicin is feasible; it appears not to add substantial toxicity compared to doxorubicin alone. Pharmacodynamic study supports this concept. The recommended dose for the phase II part for doxorubicin was 75 mg/m2. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 4 | 40% |
United States | 2 | 20% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 70% |
Scientists | 1 | 10% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 13% |
Researcher | 5 | 13% |
Student > Bachelor | 4 | 10% |
Librarian | 3 | 8% |
Professor | 3 | 8% |
Other | 9 | 23% |
Unknown | 11 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 40% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Engineering | 2 | 5% |
Mathematics | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 12 | 30% |